CD BioSciences
A polyphenol flavonoid that displays antitumor and antioxidant properties. Inhibits telomerase and DNA methyltransferase (DNMT) and blocks the activation of EGF receptors and HER-2 receptors. Also potently and specifically inhibits chymotrypsin-like activity of the proteasome in vitro (IC50= 86-194 nM) and in vivo (IC50 =1 -10 µM).
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(+-)-Bay K 8644
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CD BioSciences
A L-type Ca2+-channel activator (EC50 = 17.3 nM). In combination with BIX01294 , enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts.
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CD BioSciences
Usnic acid is a polyphenolic compound that is found in lichens. It has been shown to have potent antioxidant and anticancer properties. Usnic acid inhibits mitochondrial respiration by binding to the complex I of the electron transport chain, thereby preventing proton pumping. This leads to a decrease in the mitochondrial membrane potential, which may result […]
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(±)-Thalidomide
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CD BioSciences
Cell-permeable. A teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Thalidomide initiates its teratogenic effects by binding to cereblon (CRBN), a thalidomide-binding protein, and inhibiting the associated ubiquitin ligase activity.
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CD BioSciences
[(2-Furanylmethyl)sulfinyl]-acetic acid is an anti-aging agent that belongs to the class of silicone compounds. It can be cross-linked with zinc methacrylate to form a high-temperature resistant, silicone polymer. [(2-Furanylmethyl)sulfinyl]-acetic acid has been shown to interact with amides and fatty acids, preventing the production of peroxides at higher temperatures. This compound also has anti-inflammatory properties and […]
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