Creative Biolabs is a leading company of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world. Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price.
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Cetuximab is an epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions. Cetuximab is marketed under the brand Erbitux® by Eli Lilly and […]
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Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain […]
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ADCs Toxins, Cinerubin B is described as an antibiotic compound. HCT-116: IC50=0,0006 uM; PSN1 : IC50=0,0012 uM; T98G : IC50=0,0012 uM; A549 : IC50=0,0006 uM (preliminary laboratory results). Biological & Pharmaceutical Bulletin (2006), 29(10), 1999-2003, Journal of Antibiotics (1981),34(12), 1596-1607.
More Information Supplier PageHuman Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence […]
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Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
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ADCs Toxins, Colchicine is a mitosis inhibitor useful in cell division studies.
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Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren’s contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie’s disease, a connective tissue disorder involving the growth of fibrous […]
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ADCs Toxins, Combretastatin-A4 is a potent tubulin polymerization inhibitor. Comretastatin-A4 displays a strong inhibition on tumor cell growth.
More Information Supplier PageADCs Toxins, HCT-116: IC50=0,86 µM; PSN1 : IC50=0,86 µM; T98G : IC50=>8,62 µM; A549 : IC50=>8,62 µM (preliminary laboratory results).
More Information Supplier PageADCs Toxins, Cordycepin from Cordyceps militaris. Cordycepin blocks revovery of non-heat-shock mRNA translation following heat shock in Drosophilla. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotide transferase-positive leukemic cells has been reported. Cordycepin blocks the Smad signaling by 3`-deoxyadenosine (a mechanism for its anti-fibriotic potential).
More Information Supplier PageADCs Toxins, Cryptophycins are potent microtubule inhibitors, with a mechanism of action similar to that of paclitaxel and vinca alkaloids. Treatment of cells with cryptophycins depletes microtubules through interaction with tubulin, thereby preventing cell division. Cryptophycins are capable of inducing apoptosis, possibly through other mechanisms in addition to that mediated by microtubule inhibition.
More Information Supplier PageADCs Toxins, Cucurbitacin B is a oxygenated triterpenoid molecule predominantly found in different species of the Cucurbitaceae family. One of its most relevant acticity, is the cytotoxic effects towards human cancer cell lines e.g. breast, lung, prostate, and human colon. A recent study from Marostica et al investigates the synergistic antiproliferative effects of a new […]
More Information Supplier PageADCs Toxins, Cucurbitacin E is a tetracyclic triterpene, isolated from cucurbitaceous plants. It has been reported to possess anti-inflammatory and antiproliferative effects mediated by its action on the polymerisation of the actin cytoskeleton. Many cancer preventive properties have been reported. CuE induces cell cycle arrest and apoptosis in human breast cancer cell lines. It promotes […]
More Information Supplier PageADCs Toxins, Curvulin is a phytotoxin. Curvulin is an microtubule assembly inhibitor.
More Information Supplier PageADCs Toxins, Cyclopamine is a Hedgehog signaling pathway inhibitor. Cyclopamine inhibits the growth of medulloblastoma cells. Activation of the hedgehog (HH) pathway plays a critical role in the development and continued growth of pancreatic adenocarcinoma (PAC). Cyclopamine, a HH pathway inhibitor, has been shown to suppress PAC cell proliferation in vitro and in vivo. However, […]
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Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining […]
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Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
More Information Supplier PageADCs cytotoxin, Daun02 is a daunorubicin b-galactoside prodrug for use in conjunction.
More Information Supplier PageADCs cytotoxin, Daunorubicin(RP13057) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
More Information Supplier PageADCs Toxins, Daunorubicin HCl is a chemotherapeutic of the anthracycline family. It is mainly used to treat acute myeloid leukemia and acute lymphocytic leukemia. The biochemical mode of action is the inhibition of DNA and RNA synthesis as sequence specific ds-DNA interacting agent. Daunomycin binds to every 3 base pairs and induces a local unwinding […]
More Information Supplier PageADCs cytotoxin, Daunorubicin Hcl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
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A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
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Creative Biolabs offers high-quality services of human immunodeficiency virus type 1 (HIV-1) broadly neutralizing antibodies (bNAbs) discovery and anti-HIV peptide discovery.
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Creative Biolabs is dedicated to offering first-class influenza virus bNAbs discovery and antimicrobial peptides (AMPs) discovery service to meet your development goal in a time-saving manner.
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Creative Biolabs is pleased to use our extensive experience and advanced anti-virus biomolecular discovery system to offer the best Ebola virus NAbs and functional peptide discovery service to satisfy each demand from our customers.
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Creative Biolabs has accumulated extensive experience in anti-virus biomolecular discovery. Our scientists are dedicated to offering first-class SARS-CoV neutralizing antibody and peptide discovery services.
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ADCs Toxins, Used in molecular biology. DTT preserves proteins of interiors of cells in their functional form by avoiding the oxidation of Sulfhidril-groups (SH-) into disulifidbridges through atmospheric oxygen. On the other hand the convolution of proteins whose structure is stabilised by disulfidbridges may be destroyed by their reduction. It is an important reagent in […]
More Information Supplier PageADCs Toxins, Used in molecular biology. DTT preserves proteins of interiors of cells in their functional form by avoiding the oxidation of Sulfhidril-groups (SH-) into disulifidbridges through atmospheric oxygen. On the other hand the convolution of proteins whose structure is stabilised by disulfidbridges may be destroyed by their reduction. It is an important reagent in […]
More Information Supplier PageADCs Toxins, Used in molecular biology. DTT preserves proteins of interiors of cells in their functional form by avoiding the oxidation of Sulfhidril-groups (SH-) into disulifidbridges through atmospheric oxygen. On the other hand the convolution of proteins whose structure is stabilised by disulfidbridges may be destroyed by their reduction. It is an important reagent in […]
More Information Supplier PageADCs Toxins, DM1 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
More Information Supplier PageADCs Toxins, DM4 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
More Information Supplier PageADCs cytotoxin, Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly.
More Information Supplier PageADCs Toxins, Dolastatin 15 may be a useful tubulin-targeting payload for the conjugation at various antibody reactive sites, depending on the used linker technology. IC50 value 23 µM (Bai et al. 1992). Dolastatin 15 is a Tubulin inhibitor.
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Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products without affecting […]
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Linker-Toxin SET, INNO-206 (Aldoxorubicin) is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, doxorubicin prodrug INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety.
More Information Supplier PageADCs cytotoxin, Doxorubicin(Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
More Information Supplier PageADCs cytotoxin, Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
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Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective […]
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ADCs Toxins, Duocarmycins, which were first isolated from Streptomyces bacteria in 1988, have shown activity in a variety of multi-drug resistant (MDR) models. Agents that are part of this class of duocarmycins have the potency in the low picomolar range. This makes them suitable for maximizing the cell-killing potency of antibody-drug conjugates to which they […]
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Soliris is a formulation of eculizumab which is a recombinant humanized monoclonal IgG2/4;κ antibody produced by murine myeloma cell culture and purified by standard bioprocess technology. Eculizumab contains human constant regions from human IgG2 sequences and human IgG4 sequences and murine complementarity-determining regions grafted onto the human framework light- and heavy-chain variable regions. Eculizumab is […]
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Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
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Enfuvirtide is a 36 residue synthetic peptide that inhibits HIV-1 fusion with CD4 cells. It is an N-terminal acetylated, C-terminal amide. As an HIV fusion inhibitor, it is the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.
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