Creative Biolabs

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Creative Biolabs is a leading company of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world. Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price.

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Abatacept 1 mg  | >90%

Creative Biolabs

Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two […]

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Abciximab 1 mg  | >90%

Creative Biolabs

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and […]

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Adalimumab 1 mg  | >90%

Creative Biolabs

Adalimumab is a human monoclonal antibody against TNF-alpha. It is produced by recombinant DNA technology using a mammalian cell expression system. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons.

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Agalsidase beta 1 mg  | >90%

Creative Biolabs

Recombinant human alpha-galactosidase A. The mature protein is composed of 2 subunits of 398 residues. Protein is glycosylated and produced by CHO cells

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Aldesleukin 1 mg  | >90%

Creative Biolabs

Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following […]

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Alefacept 1 mg  | >90%

Creative Biolabs

Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD.

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Alemtuzumab 1 mg  | >90%

Creative Biolabs

Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian […]

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Alglucerase 1 mg  | >90%

Creative Biolabs

Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated with mannose residues

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Alglucosidase alfa 1 mg  | >90%

Creative Biolabs

Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell line. Alglucosidase alfa degrades glycogen […]

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Alpha-1-proteinase inhibitor 1 mg  | >90%

Creative Biolabs

Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

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alpha-Amanitin – fungal fermentation origin 1 mg  | >95%

Creative Biolabs

ADCs Toxins, alpha-Amanitin, a cyclic peptide, consisting of eight amino acids.The source of this specific alpha-Amanitin is fungal fermentation. By this production method the supply problems are solved. alpha-Amanitin is an inhibitor of RNA polymerase II (0.02 micrograms/ml). RNA polymerase I was also inhibited by the relatively high concentration of alpha-amanitin (IC50 = 100 micrograms/ml […]

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Anakinra 1 mg  | >90%

Creative Biolabs

Anakinra is a recombinant, nonglycosylated human interleukin-1 receptor antagonist (IL-1Ra). The difference between anakinra and the native human IL-1Ra is that anakinra has an extra methionine residue at the amino terminus. It is manufactured by using the E. coli expression system. Anakinra is composed of 153 amino acid residues. FDA approved on November 14, 2001.

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Anistreplase 1 mg  | >90%

Creative Biolabs

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.

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Ansamitocin P-3 1 mg  | >85%

Creative Biolabs

ADCs cytotoxin, Ansamitocin P-3, a potent anti-tumor maytansinoid found in Actinosynnema pretiosum, is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29.

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Antithrombin Alfa 1 mg  | >90%

Creative Biolabs

Therapeutic proteins are proteins that are engineered in the laboratory for pharmaceutical use, including noncovalent binders, proteins that affect covalent bonds which are almost all enzymes, and albumin.

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Arcitumomab 1 mg  | >90%

Creative Biolabs

Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. The molecule has a molecular weight of ~54,000 Daltons.

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Auristatin E 1 mg  | >95%

Creative Biolabs

ADCs cytotoxin, Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

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Auristatin F 1 mg  | >95%

Creative Biolabs

ADCs cytotoxin, Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.

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Basiliximab 1 mg  | >90%

Creative Biolabs

A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express […]

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Becaplermin 1 mg  | >90%

Creative Biolabs

Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds.

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beta-Amanitin 1 mg  | >95%

Creative Biolabs

ADCs Toxins, beta-Amanitin, a cyclic peptide, consisting of eight amino acids is part of the toxic peptide group of the Amanita phalloides mushroom. beta-Amanitin inhibits mammalian protein synthesis.It is an inhibitor of RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase.

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Bevacizumab 1 mg  | >90%

Creative Biolabs

A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing […]

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Bivalirudin 1 mg  | >90%

Creative Biolabs

Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, […]

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Botulinum Toxin Type B 1 mg  | >90%

Creative Biolabs

Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps.

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Capromab 1 mg  | >90%

Creative Biolabs

Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Capromab is used to image the […]

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Cetuximab 1 mg  | >90%

Creative Biolabs

Cetuximab is an epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions. Cetuximab is marketed under the brand Erbitux® by Eli Lilly and […]

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Choriogonadotropin alfa 1 mg  | >90%

Creative Biolabs

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain […]

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Cinerubin B 1 mg  | >95%

Creative Biolabs

ADCs Toxins, Cinerubin B is described as an antibiotic compound. HCT-116: IC50=0,0006 uM; PSN1 : IC50=0,0012 uM; T98G : IC50=0,0012 uM; A549 : IC50=0,0006 uM (preliminary laboratory results). Biological & Pharmaceutical Bulletin (2006), 29(10), 1999-2003, Journal of Antibiotics (1981),34(12), 1596-1607.

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Coagulation Factor IX 1 mg  | >90%

Creative Biolabs

Human Factor IX protein, produced by recombinant DNA technology for use in therapy of factor IX deficiency, known as hemophilia B or Christmas disease. Coagulation Factor IX (Recombinant) is a glycoprotein with an approximate molecular mass of 55,000 Da consisting of 415 amino acids in a single chain. It has a primary amino acid sequence […]

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Coagulation factor VIIa Recombinant Human 1 mg  | >90%

Creative Biolabs

Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.

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Collagenase clostridium histolyticum 1 mg  | >90%

Creative Biolabs

Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren’s contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie’s disease, a connective tissue disorder involving the growth of fibrous […]

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Combretastatin-A4 1 mg  | >95%

Creative Biolabs

ADCs Toxins, Combretastatin-A4 is a potent tubulin polymerization inhibitor. Comretastatin-A4 displays a strong inhibition on tumor cell growth.

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Compound CL0485 1 mg  | >95%

Creative Biolabs

ADCs Toxins, HCT-116: IC50=0,86 µM; PSN1 : IC50=0,86 µM; T98G : IC50=>8,62 µM; A549 : IC50=>8,62 µM (preliminary laboratory results).

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Cordycepin 1 mg  | >95%

Creative Biolabs

ADCs Toxins, Cordycepin from Cordyceps militaris. Cordycepin blocks revovery of non-heat-shock mRNA translation following heat shock in Drosophilla. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotide transferase-positive leukemic cells has been reported. Cordycepin blocks the Smad signaling by 3`-deoxyadenosine (a mechanism for its anti-fibriotic potential).

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Cryptophycin 1 mg  | >95%

Creative Biolabs

ADCs Toxins, Cryptophycins are potent microtubule inhibitors, with a mechanism of action similar to that of paclitaxel and vinca alkaloids. Treatment of cells with cryptophycins depletes microtubules through interaction with tubulin, thereby preventing cell division. Cryptophycins are capable of inducing apoptosis, possibly through other mechanisms in addition to that mediated by microtubule inhibition.

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Cucurbitacin B 1 mg  | >95%

Creative Biolabs

ADCs Toxins, Cucurbitacin B is a oxygenated triterpenoid molecule predominantly found in different species of the Cucurbitaceae family. One of its most relevant acticity, is the cytotoxic effects towards human cancer cell lines e.g. breast, lung, prostate, and human colon. A recent study from Marostica et al investigates the synergistic antiproliferative effects of a new […]

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Cucurbitacin E 1 mg  | >95%

Creative Biolabs

ADCs Toxins, Cucurbitacin E is a tetracyclic triterpene, isolated from cucurbitaceous plants. It has been reported to possess anti-inflammatory and antiproliferative effects mediated by its action on the polymerisation of the actin cytoskeleton. Many cancer preventive properties have been reported. CuE induces cell cycle arrest and apoptosis in human breast cancer cell lines. It promotes […]

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Cyclopamine, Free Base 1 mg  | >95%

Creative Biolabs

ADCs Toxins, Cyclopamine is a Hedgehog signaling pathway inhibitor. Cyclopamine inhibits the growth of medulloblastoma cells. Activation of the hedgehog (HH) pathway plays a critical role in the development and continued growth of pancreatic adenocarcinoma (PAC). Cyclopamine, a HH pathway inhibitor, has been shown to suppress PAC cell proliferation in vitro and in vivo. However, […]

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Daclizumab 1 mg  | >90%

Creative Biolabs

Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining […]

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Darbepoetin alfa 1 mg  | >90%

Creative Biolabs

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

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