ADCs Toxins, Used in molecular biology. DTT preserves proteins of interiors of cells in their functional form by avoiding the oxidation of Sulfhidril-groups (SH-) into disulifidbridges through atmospheric oxygen. On the other hand the convolution of proteins whose structure is stabilised by disulfidbridges may be destroyed by their reduction. It is an important reagent in […]
More Information Supplier PageADCs Toxins, Used in molecular biology. DTT preserves proteins of interiors of cells in their functional form by avoiding the oxidation of Sulfhidril-groups (SH-) into disulifidbridges through atmospheric oxygen. On the other hand the convolution of proteins whose structure is stabilised by disulfidbridges may be destroyed by their reduction. It is an important reagent in […]
More Information Supplier PageADCs Toxins, Daunorubicin HCl is a chemotherapeutic of the anthracycline family. It is mainly used to treat acute myeloid leukemia and acute lymphocytic leukemia. The biochemical mode of action is the inhibition of DNA and RNA synthesis as sequence specific ds-DNA interacting agent. Daunomycin binds to every 3 base pairs and induces a local unwinding […]
More Information Supplier PageADCs Toxins, Cyclopamine is a Hedgehog signaling pathway inhibitor. Cyclopamine inhibits the growth of medulloblastoma cells. Activation of the hedgehog (HH) pathway plays a critical role in the development and continued growth of pancreatic adenocarcinoma (PAC). Cyclopamine, a HH pathway inhibitor, has been shown to suppress PAC cell proliferation in vitro and in vivo. However, […]
More Information Supplier PageADCs Toxins, Ferulenol is an cytotoxic Anti-tumor compound. Ferulenol inhibits the colchicine binding to tubulin. It is an Antitubercular antibiotic with potent antibacterial activity. Ferulenol is isolated from Ferula communis.
More Information Supplier PageADCs Toxins, Fumagillin is a methionine aminopeptidase-2 (MetAP-2) inhibitor; Fumagillin inhibits endothelial cell proliferation and angiogenesis. Fumagillin belongs to the group of mycotoxins. Origin: Aspergillus fumigatus
More Information Supplier PageADCs Toxins, Isofistularin-3 is a natural, marine alkaloid belonging to the group of bromotyrosine-derivatives. It is a cytotoxic isoxazoline compound. Isofistularin-3 shows in vitro activity against HeLa cells. It has shown antiproliferative activities against Jurkat and U937 cellts (MTT-Assay).
More Information Supplier PageADCs Toxins, Ilimaquinone is a cell permeable, antimicrobial, anti-inflammatory, antimitotic and cytotoxic compound.
More Information Supplier PageADCs Toxins, Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, […]
More Information Supplier PageADCs Toxins, Hygrolidin is a macrocyclic lactone closely related to the group of bafilomycins. Hygrolidin is active against Valsa ceratosperma, the pathogen of an apple desease called “canker disease”. Hygrolidin is active against SV40 tumour cells, and inhibits the growth of solid tumour-derived cell lines.HCT-116: IC50=0,0014 uM; PSN1 : IC50=0,72 uM; T98G : IC50=1,447 uM; […]
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