Clearsynth

Clearsynth is a technology based, research driven enterprise with the World's Largest Inventory of Reference Standards & Research Chemicals. We aim to enable the research community in accelerated discovery via synthesis of complex and difficult to make compounds. We specialize in Innovative Organic chemistry and synthesis of Unique Complex Molecules, Stable Isotope Labelled compounds, Metabolites, Impurities, Glucuronides, Chiral Compounds, Conjugate Impurities, and Radioactive Labelled Compounds. We also undertake synthesis of complex Molecules or "Difficult to Synthesize" compounds/Intermediates. We have a strong commitment towards improving our quality systems, to deliver products that meet and exceed the needs of our customers and regulatory body mandates.

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1H-1,2,3-benzotriazol-1-ol 500 g  | >98%

Clearsynth

Fine Chemical

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1H-1,2,3-benzotriazol-1-ol

1R,3S,aS-Deltamethrin 500 g  | >98%

Clearsynth

trans-Deltamethrin, is trans isomer of Deltamethrin , a synthetic pyrethroid insecticide, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC50 of about 100pM.

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1R,3S,aS-Deltamethrin

2 Methyl 3 nitrophenol 500 g  | >98%

Clearsynth

Fine Chemical

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2 Methyl 3 nitrophenol

2- Epi Docetaxel 500 g  | >98%

Clearsynth

Impurities

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2- Epi Docetaxel

2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene 500 g  | >98%

Clearsynth

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2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene

2-(2-Aminothiazol-4-yl)acetic acid hydrochloride 500 g  | >98%

Clearsynth

Fine Chemical

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2-(2-Aminothiazol-4-yl)acetic acid hydrochloride

2-(2-Bromoethyl)-1,3-dioxane 500 g  | >98%

Clearsynth

Building Blocks

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2-(2-Bromoethyl)-1,3-dioxane

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 500 g  | >98%

Clearsynth

Vardenafil intermediate.

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2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid 500 g  | >98%

Clearsynth

Intermediate in the preparation of MEK inhibitors.

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2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

2-(2-Methoxyphenoxy)ethylamine hydrochloride 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Carvedilol

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2-(2-Methoxyphenoxy)ethylamine hydrochloride

2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 500 g  | >98%

Clearsynth

Fine Chemicals

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2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile

2-(2,2,2-Trifluoroethoxy)phenol 500 g  | >98%

Clearsynth

Fine Chemical

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2-(2,2,2-Trifluoroethoxy)phenol

2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol 500 g  | >98%

Clearsynth

Impurities

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2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol

2-(2,6-Dichlorophenyl)ethanol 500 g  | >98%

Clearsynth

Fine Chemical

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2-(2,6-Dichlorophenyl)ethanol

2-(4-(Benzyloxy)-3-methoxy-2-nitrophenyl)-4,5-dihydro-1H-imidazole 500 g  | >98%

Clearsynth

Fine chemicals

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2-(4-(Benzyloxy)-3-methoxy-2-nitrophenyl)-4,5-dihydro-1H-imidazole

2-(4-(tert-Butoxy)phenyl)ethanol 500 g  | >98%

Clearsynth

Fine Chemical

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2-(4-(tert-Butoxy)phenyl)ethanol

2-(4-fluorophenyl)-5-(2-methylbenzyl)thiophene 500 g  | >98%

Clearsynth

Impurity in commercial preparation of Canagliflozin.

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2-(4-fluorophenyl)-5-(2-methylbenzyl)thiophene

2-(4-Hydroxy-phenyl)-3-methyl-1H-indole-5-ol 500 g  | >98%

Clearsynth

Impurity in commercial preparation of Bazedoxifene.

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2-(4-Hydroxy-phenyl)-3-methyl-1H-indole-5-ol

2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide 500 g  | >98%

Clearsynth

2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide is an ring-opened impurity of Ezetimibe .

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2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide

2-(4-Octylphenyl)ethanol 500 g  | >98%

Clearsynth

Fine Chemical

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2-(4-Octylphenyl)ethanol

2-(7-ethyl-1h-indol-3-yl)ethanol 500 g  | >98%

Clearsynth

Key intermediate in the preparation of the non-steroidal anti-inflammatory drug Etodolac.

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2-(7-ethyl-1h-indol-3-yl)ethanol

2-(Di-t-butylphosphino)biphenyl 500 g  | >98%

Clearsynth

Fine Chemical

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2-(Di-t-butylphosphino)biphenyl

2-(Diisopropylamino)ethylamine 500 g  | >98%

Clearsynth

Fine Chemicals

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2-(Diisopropylamino)ethylamine

2-(Methylamino)ethanol 500 g  | >98%

Clearsynth

Intermediates

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2-(Methylamino)ethanol

2-(N-Phenyl-N-benzyl-aminomethyl)-imidazol 500 g  | >98%

Clearsynth

Drug Peptides

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2-(N-Phenyl-N-benzyl-aminomethyl)-imidazol

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde 500 g  | >98%

Clearsynth

Posaconazole intermediate. Antifungal agent.

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2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

2-[(1S,2S)-1-Ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one (N-2) 500 g  | >98%

Clearsynth

Intermediate in the preparation of Posaconazole .

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2-[(1S,2S)-1-Ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one (N-2)

2-[(2-Aminophenyl)amino]-5-methyl-3-thiophenecarbonitrile 500 g  | >98%

Clearsynth

Impurities

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2-[(2-Aminophenyl)amino]-5-methyl-3-thiophenecarbonitrile

2-[(2,6-Dichlorophenyl)amino]-N,N-dimethylbenzeneacetamide 500 g  | >98%

Clearsynth

Intermediates

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2-[(2,6-Dichlorophenyl)amino]-N,N-dimethylbenzeneacetamide

2-[(Diphenylmethyl)thio]acetamide 500 g  | >98%

Clearsynth

Deoxy Modafinil is an analogue and precursor to Modafinil (M482500), an a-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.

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2-[(Diphenylmethyl)thio]acetamide

2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Bepotastine.

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2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate

2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic Acid Methyl Ester 500 g  | >98%

Clearsynth

Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists.

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2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic Acid Methyl Ester

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine 500 g  | >98%

Clearsynth

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2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate 500 g  | >98%

Clearsynth

An intermediate of Silodosin.

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2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

2-[2-[4-(2-Azidotetrahydro-3-methyl-5-oxo-2-furanyl)phenyl]hydrazinylidene]propanedinitrile ( Diasteromers) 500 g  | >98%

Clearsynth

Impurities

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2-[2-[4-(2-Azidotetrahydro-3-methyl-5-oxo-2-furanyl)phenyl]hydrazinylidene]propanedinitrile ( Diasteromers)

2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid 500 g  | >98%

Clearsynth

2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid is an impurity of Febuxostat , an xanthine oxidase/xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout. ;Impurity in commercial preparations of Febuxostat

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2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid

2-[Methyl(phenylmethyl)amino]ethanol 500 g  | >98%

Clearsynth

2-[Methyl(phenylmethyl)amino]ethanol is used in the preparation of dihydropyrimidinones as sodium iodide symporter inhibitors used to regulate the accumulation of iodide in the thyroid gland. Also used in the synthesis of new class of pseudopeptides as potential inhibitors of ß-sheet aggregation.

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2-[Methyl(phenylmethyl)amino]ethanol

2-{(E)-[(4-fluorophenyl)imino]methyl}phenol 500 g  | >98%

Clearsynth

Impurity in commercial preparation of Ezetimibe.

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2-{(E)-[(4-fluorophenyl)imino]methyl}phenol

2-4-Dichloropyrimidine 500 g  | >98%

Clearsynth

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2-4-Dichloropyrimidine

2-Acetamido-4-fluoro-1,3,6-tri-O-acetyl-2,4-dideoxy-D-glucopyranose 500 g  | >98%

Clearsynth

Impurities

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2-Acetamido-4-fluoro-1,3,6-tri-O-acetyl-2,4-dideoxy-D-glucopyranose

2-Acetyl Phenothiazine 500 g  | >98%

Clearsynth

2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

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2-Acetyl Phenothiazine

2-Acetyl-1-Pyrroline 500 g  | >98%

Clearsynth

Fine Chemical

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2-Acetyl-1-Pyrroline

2-Acetylpyridine 500 g  | >98%

Clearsynth

Fine Chemical

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2-Acetylpyridine

2-Amino-2-methylpropanol 500 g  | >98%

Clearsynth

Fine Chemical

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2-Amino-2-methylpropanol

2-Amino-2',5-dichlorobenzophenone 500 g  | >98%

Clearsynth

Lorazepam Impurity A. ;Impurity in commercial preparations of Lorazepam; Lorazepam EP Impurity A

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2-Amino-2',5-dichlorobenzophenone

2-Amino-3-benzyloxypyridine 500 g  | >98%

Clearsynth

2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.

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2-Amino-3-benzyloxypyridine

2-Amino-3-iodobenzoic acid 500 g  | >98%

Clearsynth

Fine Chemical

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2-Amino-3-iodobenzoic acid

2-Amino-4-chlorophenol 500 g  | >98%

Clearsynth

2-Amino-4-chlorophenol is a widely used reagent in the synthesis of various drugs, dyes and pesticides. A reagent in the synthesis of aggrecanase-2 inhibitors based on acylthiosemicarbazide zinc-binding, used in the treatment of osteoarthritis.

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2-Amino-4-chlorophenol

2-Amino-4-iodobenzoic acid 500 g  | >98%

Clearsynth

Fine Chemical

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2-Amino-4-iodobenzoic acid

2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride 500 g  | >98%

Clearsynth

Intermediates

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2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride