ADCs Toxins, 9-Hydroxyellipticine hydrochloride is a cell-permeable antitumor alkaloid that acts as a potent inhibitor of topoisomerase II. IC50=3.3 µM. Synthetic source.
More Information Supplier PageADCs Toxins, Herboxidiene is described as a microbial product with antitumor activity. Herboxidiene seems to serve as a novel splicing inhibitor that specifically impairs the SF3b function by binding to SAP155. Herboxidiene in house activity data obtained from our manufacturing partner: Cellular line A549 (lung cander) IC50: 0,036 ug/ml – IC50 82 uM; Cellular line […]
More Information Supplier PageADCs Toxins, Amino Acid Sequence: HCO-X-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-NHCH2CH2OH – Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes. Gramicidin A increases the permeability of bacterial cell membranes which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment. HCT-116: IC50=0,44 […]
More Information Supplier PageADCs Toxins, Glucopiericidin A is a natural bioactive compound. Glucopiericidin A (GPA) interestingly alone did not inhibit filopodia protrusion, but synergistically inhibit protrusion with the mitochondrial respiration inhibitor, piericidin A (PA). These results suggested that GPA might inhibit glycolysis. GPA may therefore serve as a glucose transporter chemical probe. Simultaneous inhibition of both glycolysis and […]
More Information Supplier PageADCs Toxins, Geldanamycin is a benzoquinone ansamycin antibiotic. Geldamycin is among other things used to cure cancer patients. It specifically ties up to the heat shock proteine HSP 90 (Heat Shock Protein 90) and changes its function. The bond of Geldamycin to HSP 90 causes the decomposition of target-proteins such as Tyrosinkinasen, Steroidrezeptoren, Transkriptionsfactors and […]
More Information Supplier PageADCs Toxins, DM4 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
More Information Supplier PageADCs Toxins, DM1 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
More Information Supplier PageADCs Toxins, A maytansinoid is a chemical derivative of maytansine being investigated as the cytotoxic component of antibody-drug conjugates. Anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function.
More Information Supplier PageADCs Toxins, Tubulysins show a very high cytotoxic activity against in vitro and in vivo tumor models, especially against resistant tumor cell lines. Many representatives of these natural products are several orders of magnitude more potent than other available chemotheraprutics. Based on the SAR of the tubulysins this class allows for many chemical conjugation and […]
More Information Supplier PageADCs cytotoxin, Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.
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