ADCs Toxins, Amino Acid Sequence: HCO-X-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-NHCH2CH2OH – Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes. Gramicidin A increases the permeability of bacterial cell membranes which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment. HCT-116: IC50=0,44 µM; PSN1 : IC50=>0,53 µM; T98G : IC50=>2,66 µM; A549 : IC50=0,35 µM (preliminary laboratory results)