Selleck Chemicals

Selleck Chemicals logo

Selleck Chemicals supplies over 3,000 inhibitors used in the study of cell signaling pathways. We actively tracks the latest science so our customers can rely on us to be the leading supplier of the newest inhibitors.

Company Website

Product Listing

(E)-Cardamonin 25mg  | Purity Not Available

Selleck Chemicals

(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.

More Information Supplier Page

(E/Z)-BCI 25mg  | Purity Not Available

Selleck Chemicals

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

More Information Supplier Page

(E/Z)-BCI 5mg  | Purity Not Available

Selleck Chemicals

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

More Information Supplier Page

(L)-Dehydroascorbic acid 25mg  | Purity Not Available

Selleck Chemicals

(L)-Dehydroascorbic acid (DHA) is an oxidized form of l-Ascorbic acid (AsA) that efficiently scavenges non-thermal plasma-induced hydroxyl radicals in the presence of thiols and fails to scavenge hydroxyl radicals by itself.

More Information Supplier Page

(R)-(-)-Gossypol acetic acid 50mg  | Purity Not Available

Selleck Chemicals

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

More Information Supplier Page

(R)-(-)-Gossypol acetic acid 10mg  | Purity Not Available

Selleck Chemicals

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

More Information Supplier Page

(R)-(-)-Gossypol acetic acid 10mM/1mL  | Purity Not Available

Selleck Chemicals

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

More Information Supplier Page

(R)-3-Hydroxybutanoic acid 25mg  | Purity Not Available

Selleck Chemicals

(R)-3-Hydroxybutanoic acid (R-3HB, D-3-hydroxybutyric acid) is a monomer of PHB (poly[(R)-3-hydroxybutyrate]) with wide industrial and medical applications. (R)-3-hydroxybutyric acid can also serve as chiral precursor for synthesis of pure biodegradable PHB and its copolyesters.

More Information Supplier Page

(R)-baclofen 10mg  | Purity Not Available

Selleck Chemicals

(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

More Information Supplier Page

(R)-baclofen 50mg  | Purity Not Available

Selleck Chemicals

(R)-baclofen (STX 209) is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

More Information Supplier Page

(R)​-​CR8 2mg  | Purity Not Available

Selleck Chemicals

(R)​-​CR8 is the second-generation analog of Roscovitine and a potent CDK1/2/5/7/9 inhibitor. (R)​-​CR8 inhibits CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK7/cyclin H, CDK9/cyclin T and CK1δ/ε with IC50 of 0.09 μM, 0.072 μM, 0.041 μM, 0.11 μM, 1.1 μM, 0.18 μM and 0.4 μM, respectively. (R)​-​CR8 induces apoptosis and has neuroprotective effect.

More Information Supplier Page

(R)-GNE-140 2mg  | Purity Not Available

Selleck Chemicals

(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.

More Information Supplier Page

(R)-GNE-140 5mg  | Purity Not Available

Selleck Chemicals

(R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.

More Information Supplier Page

(R)-Nepicastat HCl 10mg  | Purity Not Available

Selleck Chemicals

(R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

More Information Supplier Page

(R)-Nepicastat HCl 50mg  | Purity Not Available

Selleck Chemicals

(R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

More Information Supplier Page

(R)-P7C3-Ome 5mg  | Purity Not Available

Selleck Chemicals

(R)-P7C3-Ome is an analogue of P7C3 and P3C3-A20. (R)-P7C3-Ome has therapeutic benefits in neuropsychiatric and/or neurodegenerative disease and is far more active than the S-enantiomer.

More Information Supplier Page

(R)-P7C3-Ome 25mg  | Purity Not Available

Selleck Chemicals

(R)-P7C3-Ome is an analogue of P7C3 and P3C3-A20. (R)-P7C3-Ome has therapeutic benefits in neuropsychiatric and/or neurodegenerative disease and is far more active than the S-enantiomer.

More Information Supplier Page

(R)-Serine 25mg  | Purity Not Available

Selleck Chemicals

(R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. (R)-Serine acts as obligatory coagonist at the glycine site associated with the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) and has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

More Information Supplier Page

(R)-Viloxazine Hydrochloride 5mg  | Purity Not Available

Selleck Chemicals

(R)-Viloxazine Hydrochloride is the R-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant.

More Information Supplier Page

(Rac)-Antineoplaston A10 25mg  | Purity Not Available

Selleck Chemicals

(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10. Antineoplaston A10 is an inhibitor of Ras that is potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

More Information Supplier Page

(Rac)-Antineoplaston A10 5mg  | Purity Not Available

Selleck Chemicals

(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10. Antineoplaston A10 is an inhibitor of Ras that is potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

More Information Supplier Page

(Rac)-JBJ-04-125-02 25mg  | Purity Not Available

Selleck Chemicals

(Rac)-JBJ-04-125-02 (JBJ-04-125-02 racemate) is a mutant-selective allosteric inhibitor of Epidermal growth factor receptor (EGFR) with potential anticancer activity.

More Information Supplier Page

(Rac)-JBJ-04-125-02 5mg  | Purity Not Available

Selleck Chemicals

(Rac)-JBJ-04-125-02 (JBJ-04-125-02 racemate) is a mutant-selective allosteric inhibitor of Epidermal growth factor receptor (EGFR) with potential anticancer activity.

More Information Supplier Page

(S,R,S)-AHPC (MDK7526) 25mg  | Purity Not Available

Selleck Chemicals

(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 […]

More Information Supplier Page

(S,R,S)-AHPC (MDK7526) 5mg  | Purity Not Available

Selleck Chemicals

(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 […]

More Information Supplier Page

(S,R,S)-AHPC hydrochloride 100mg  | Purity Not Available

Selleck Chemicals

(S,R,S)-AHPC hydrochloride (VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.

More Information Supplier Page

(S,R,S)-AHPC-PEG4-NH2 hydrochloride 5mg  | Purity Not Available

Selleck Chemicals

(S,R,S)-AHPC-PEG4-NH2 hydrochloride (VH032-PEG4-NH2 hydrochloride, VHL Ligand-Linker Conjugates 4 hydrochloride, E3 ligase Ligand-Linker Conjugates 7) is a PROTAC E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker.

More Information Supplier Page

(S,R,S)-AHPC-PEG4-NH2 hydrochloride 25mg  | Purity Not Available

Selleck Chemicals

(S,R,S)-AHPC-PEG4-NH2 hydrochloride (VH032-PEG4-NH2 hydrochloride, VHL Ligand-Linker Conjugates 4 hydrochloride, E3 ligase Ligand-Linker Conjugates 7) is a PROTAC E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker.

More Information Supplier Page

(S)-(-)-1-Phenylethanol 100mg  | Purity Not Available

Selleck Chemicals

(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.

More Information Supplier Page

(S)-(−)-Limonene 25ul  | Purity Not Available

Selleck Chemicals

(S)-(−)-Limonene, a fragrance monoterpene mainly found in citrus peel oil, is also naturally occurs in the essential oils of herbs, tea tree oil, and turpentine oil.

More Information Supplier Page

(S)-2-Hydroxy-3-phenylpropanoic acid 25mg  | Purity Not Available

Selleck Chemicals

(S)-2-Hydroxy-3-phenylpropanoic acid (L-(-)-3-Phenyllactic acid, (2S)-2-Hydroxy-3-phenylpropanoic acid) is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid.

More Information Supplier Page

(S)-crizotinib 5mg  | Purity Not Available

Selleck Chemicals

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.

More Information Supplier Page

(S)-crizotinib 20mg  | Purity Not Available

Selleck Chemicals

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.

More Information Supplier Page

(S)-Leucic acid 25mg  | Purity Not Available

Selleck Chemicals

Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein.

More Information Supplier Page

(S)-Viloxazine Hydrochloride 5mg  | Purity Not Available

Selleck Chemicals

(S)-Viloxazine Hydrochloride is the S-isomer of Viloxazine, a selective norepinephrine reuptake inhibitor (NRI) that can be used as an antidepressant.

More Information Supplier Page

0375-0604 (KRAS inhibitor-9) 25mg  | Purity Not Available

Selleck Chemicals

0375-0604 (KRAS inhibitor-9, DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. 0375-0604 (KRAS inhibitor-9, DUN09716) causes G2/M cell cycle arrest and induces apoptosis.

More Information Supplier Page

1-Aminobenzotriazole 100mg  | Purity Not Available

Selleck Chemicals

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

More Information Supplier Page

1-Aminobenzotriazole 25mg  | Purity Not Available

Selleck Chemicals

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

More Information Supplier Page