Sulforaphane is an isothiocyanate found in cruciferous vegetables such as broccoli. It has anti-cancer activity and targets multiple pathways in cancer development. It induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression and inhibits class I and II Histone Deacetylase activity. It induces the production of detoxifying enzymes such as quinone reductase and glutathione […]

mTOR inhibitor with anti-cancer activity. It has anti-angiogenic effects which may contribute to the antitumor activity of temsirolimus observed in breast cancer. Temsirolimus shows synergistic in vivo anti-myeloma effects in combination with dexamethasone in a xenograft model.

Tert-butyl hydrogen phthalate is an organic chemical that is used in the production of polyvinyl chloride, butyral, and polypropylene. It is also used as a plasticizer for polyvinyl acetate and polystyrene. Tert-butyl hydrogen phthalate is an anti-aging agent for vinyl, which increases its resistance to oxidation. This chemical has been shown to be effective as […]

Tetrahydrocurcumin (THC) is a major metabolite of curcumin that displays antioxidant and anti-inflammatory properties. It has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of oxidative stress. THC is being studied for the treatment of cancer and dementia. THC is also known to epigenetically ameliorate mitochondrial dysfunction in brain vasculature […]

Tetrakis(2-ethylhexyl) benzene-1,2,4,5-tetracarboxylate is a coagulant agent that can be used in the production of polyvinyl chloride. It stabilizes and prevents the formation of unwanted particles in the polymerization process by preventing the agglomeration of polymer chains. Tetrakis(2-ethylhexyl) benzene-1,2,4,5-tetracarboxylate also acts as an anti-aging agent for polyvinyl chloride and prevents deterioration due to oxidation. This compound […]

Cell-permeable. Helps in promoting human embryonic stem cell (hESC) survival by > 30-fold. Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB-431542 and PD 0325901. Acts as a Rho-associated Kinase (ROCK) inhibitor. Tzv (2 µM) inhibits ROCK activity and protect hESCs at a similar […]

A naturally occurring flavonoid that shows anti-complement, anti-inflammatory and free radical scavenger activity. Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages. Also inhibits human Low Density Lipoprotein (LDL) oxidation.

Tomatidine is a steroidal alkaloid found in the skins of unripe tomatoes. Structurally Tomatidine resembles cylopamine, but does not inhibit the Hedgehog (Hh) signaling pathway. May be used as a negative control for cyclopamine.

A potent, selective and ATP-competitive mTOR inhibitor, with IC50 values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.

A potent, selective and ATP-competitive mTOR inhibitor (IC50 = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to 440 other protein kinases.

Trans,cis-2,6-Nonadienal is a fatty acid derivative with an unsaturated 2,6-nonadiene structure. It is an inhibitor of the enzyme fatty acid synthase, which catalyzes the formation of long-chain polyunsaturated fatty acids. Trans,cis-2,6-Nonadienal has been shown to inhibit v79 cells and ester compounds that are used in analytical methods for measuring fatty acids. It is also able […]

An inhibitor of monoamine oxidase (MAO) and prostacyclin synthase. Potently suppresses the enzymatic activity of Lysine-Specific Demethylase 1 (LSD1) (IC50

Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6- methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.

Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays. Trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging. It has been shown that lipid peroxidation, cytotoxicity, and apoptosis induced […]

Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50 = 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits α-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin […]

Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms […]

Potent and selective non-competitive inhibitor of MAP kinase kinase(MEK). Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 µM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4.

A cell-permeable histone deacetylase 1 (HDAC1) inhibitor (IC50 = 400 µM) that exhibits anticancer, anti-inflammatory and neuroprotective properties. Recently it has been reported that Valproic acid enables reprogramming of primary human fibroblasts with only two factors, Oct4 and Sox2, without the need for the oncogenes c-Myc or Klf4.

Vinyltris(tert-butylperoxy)silane is a thermally and chemically stable organosilicon compound that has been used as an additive in polyolefins, and as a catalyst for the preparation of polyurethanes. It has also been used as a crosslinking agent for carboxymethylcellulose, polyvinyl alcohol, and cellulose acetate to produce water-resistant coatings. The vinyl group reacts with molybdenum trioxide to […]

Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC50 value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also helps to induce rat bone marrow stromal cells (MSCs) to neuronal cells.

Ashwagandha Extract Powder is extracted from the dried roots of wild Dramamine from South Africa. Ashwagandha Extract Powder, the main components of which are Withanolide and Withaferin , has high pharmacological value, which can treat male renal failure, promote muscle growth after exercise, treat high uric acid, relieve modern young people’s work stress, anxiety and […]

A Tankyrase (TNKS) inhibitor (IC50 = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

XL765 is a dual inhibitor of mTOR/PI3K with potential anticancer activities. XL765 inhibits both PI3 kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.

Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively. Prevents apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem cells (hES) without affecting their pluripotency.

Alpha-lipoic acid is also known as alpha-lipoic acid. alpha-lipoic acid is a light yellow powdered crystal, almost odorless. Solubility in water is small, about 1 g/L (20°C). Soluble in 10% NaOH solution, soluble in aliphatic solvents. Soluble in methanol, ethanol, chloroform, and ether. Alpha Lipoic Acid is a water-soluble and fat-soluble metabolic antioxidant, a vitamin-like […]