Creative Biolabs is a leading company of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world. Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price.
Company WebsiteADCs cytotoxin, Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.
More Information Supplier PageADCs cytotoxin, Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin.
More Information Supplier PageADCs cytotoxin, Monomethyl auristatin E (MMAE) is a hot topic in Antibody-drug conjugates (ADCs) studies.
More Information Supplier PageAntibody array is a specific form of protein microarray. In this technology, capture antibodies spotted on membranes or glass slide bind to specific target proteins present in the sample. Captured proteins are visualized using chemiluminescent or Laser Scanner. The signal produced is proportional to the amount of analyte bound. The Mouse Cytokine Antibody Array detects […]
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Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
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ADCs Toxins, Myoseverin is a microtubule-binding molecule and a reversible inhibitor of tubulin polymerization. Myoseverin is a potential angiogenesis inhibitor.
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ADCs Toxins, Cytotoxic molecule. HCT-116: IC50=0,0019 uM; PSN1 : IC50=0,0019 uM; T98G : IC50=0,0019 uM; A549 : IC50=0,0019 uM (preliminary laboratory results).
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ADCs Toxins, Calicheamicins are a group of enediyne antitumor antibiotics. Calicheamicins target DNA and cause strand scission.
More Information Supplier PageADCs Toxins, Nemorubicin is a morpholinyl analog of doxorubicin. It is more cytotoxic and less cardiotoxic against multidrug-resistant tumor cells. IC50= 0.08 µM.
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Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium.
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Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.
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ADCs Toxins, Okilactomycin is a novel antibiotic produced by a Streptomyces species. HCT-116: IC50=0,002 uM; PSN1 : IC50=0,120 uM; T98G : IC50=0,240 uM; A549 : IC50=0,240 uM (preliminary laboratory results). Journal of Antibiotics (1987), 40, 1475-82.
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ADCs Toxins, Oligomycin B is a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase and which is practically free of homologs. Oligomycin B inhibits the growth of Rhodotorula gultinis, Aspergillus niger and other moulds. Origin: Streptomyces diastatochromogenes. HCT-116: IC50=0,0012 uM; PSN1 : IC50=1,24 uM; T98G : IC50=6,21 uM; A549 : IC50=6,21 uM (preliminary laboratory results).
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A recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
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Oprelvekin, the active ingredient in Neumega® is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable […]
More Information Supplier PageADCs cytotoxin, Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
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Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli.
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Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Synagis is a composite of human (95%) and murine (5%) antibody sequences. The human heavy chain sequence was derived from the constant domains of human IgG1 and the […]
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Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa™ and Viokace™.
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Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent.
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Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.
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Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life.
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PEGylated (at N terminus) form of human G-CSF (Granulocyte colony stimulating factor), 175 residues, produced from E. coli via bacterial fermentation.
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Human interferon 2a, is a covalent conjugate of recombinant alfa-2a interferon with a single branched bis-monomethoxy polyethylene glycol (PEG) chain. The PEG moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to lysine. Peginterferon alfa-2a has an approximate molecular weight of 60,000 daltons. Interferon alfa-2a is produced […]
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Peginterferon alfa-2b is a covalent conjugate of recombinant alfa-2b interferon with monomethoxy polyethylene glycol (PEG). The average molecular weight of the PEG portion of the molecule is 12,000 daltons. The average molecular weight of the PEG-Intron molecule is approximately 31,000 daltons. The specific activity of peginterferon alfa-2b is approximately 0.7 × 108 IU/mg protein. Interferon […]
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Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
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ADCs cytotoxin, PF-06380101 is a novel cytotoxic Dolastatin 10 analogue; with excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.
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ADCs Toxins, Phallacidin is a bicyclic toxin from the Amanita phalloides mushroom. Phallacidin inhibits F-acting degradation by proteolytic enzymes including trypsin and alpha-chymotrypsin. Phallacidin is extracted i.e. from Amanita phalloides.
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ADCs Toxins, Phalloidin is a bicyclic heptapeptide toxin of the death cap mushroom toxin family aslo called phallotoxins. Phalloidin binds F-actin, preventing its depolymerization and is poisoning the cell. It specially binds at the inferface between F-acting subunits, locking adjacetn subunits togeter. Phalloidin binds specifically to polymeric and oligomeric forms of actin and not to […]
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ADCs linker, Phe-Lys(Trt)-PAB is a peptide cleavable linker for antibody-drug-conjugation (ADC).
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ADCs Toxins, Phytosphingosine is a sphingolipid endogenous to many organisms involved in cell signaling. Phytosphingosine displays anbibacterial activity (CL Fischer et al. Antimicrob. Agents Chemother. 2012 56:1157). Phytosphingosine can be taken up by E. coli and S. aureus and induce ultrastrucural damag (CL Fischer et al. Skin Pharmacol. Physiol. 2013 26:36). IC 50 value: Jurkat […]
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