Clearsynth

Clearsynth is a technology based, research driven enterprise with the World's Largest Inventory of Reference Standards & Research Chemicals. We aim to enable the research community in accelerated discovery via synthesis of complex and difficult to make compounds. We specialize in Innovative Organic chemistry and synthesis of Unique Complex Molecules, Stable Isotope Labelled compounds, Metabolites, Impurities, Glucuronides, Chiral Compounds, Conjugate Impurities, and Radioactive Labelled Compounds. We also undertake synthesis of complex Molecules or "Difficult to Synthesize" compounds/Intermediates. We have a strong commitment towards improving our quality systems, to deliver products that meet and exceed the needs of our customers and regulatory body mandates.

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(3S 4S)-3-[(R)-1-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-4-[(R)-1-CARBOXYETHYL]-2-AZETIDINONE 500 g  | >98%

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Intermediates

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(3S 4S)-3-[(R)-1-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-4-[(R)-1-CARBOXYETHYL]-2-AZETIDINONE

(3S,4S,6R)-3-Hexyl-4-hydroxy-6-undecyltetrahydro-2H-pyran-2-one 500 g  | >98%

Clearsynth

Fine Chemicals

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(3S,4S,6R)-3-Hexyl-4-hydroxy-6-undecyltetrahydro-2H-pyran-2-one

(3S,5R,6R)-Bupropion Impurity 500 g  | >98%

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Impurities

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(3S,5R,6R)-Bupropion Impurity

(3S,5S,6S)-Bupropion Impurity 500 g  | >98%

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Impurities

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(3S,5S,6S)-Bupropion Impurity

(3S,5S)-Rosuvastatin Calcium 500 g  | >98%

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(3S,5S)-Rosuvastatin Calcium

(3S,8R,9R,12S) Atazanavir 500 g  | >98%

Clearsynth

An isomer of Atazanavir.

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(3S,8R,9R,12S) Atazanavir

(3S,8S,9S,12R) Atazanavir 500 g  | >98%

Clearsynth

An isomer of Atazanavir

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(3S,8S,9S,12R) Atazanavir

(3S)-3-Amino-1-(tert-butylcarboxymethyl)-2,3,4,5-tetrahydro-1H-benzazepin-2-one 500 g  | >98%

Clearsynth

An intermediate of Benazepril.

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(3S)-3-Amino-1-(tert-butylcarboxymethyl)-2,3,4,5-tetrahydro-1H-benzazepin-2-one

(4-Carboxybutyl)triphenylphosphonium Bromide 500 g  | >98%

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Fine Chemical

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(4-Carboxybutyl)triphenylphosphonium Bromide

(4-Chloro-2-methylphenoxy)acetic Acid 500 g  | >98%

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Agro Chemicals

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(4-Chloro-2-methylphenoxy)acetic Acid

(4R-CIS)-6-HYDROXYMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID 1,1-DIMETHYLETHYL ESTER 500 g  | >98%

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(4R-CIS)-6-HYDROXYMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID 1,1-DIMETHYLETHYL ESTER

(4R,5S)-4-Methyl-5-phenyloxazolidinone 500 g  | >98%

Clearsynth

Fine Chemical

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(4R,5S)-4-Methyl-5-phenyloxazolidinone

(4R,cis)-1,1-Dimethylethyl-6-aminoethyl-2,2-dimethyl-1,3-dioxane-4-acetate 500 g  | >98%

Clearsynth

An impurity of Atorvastatin.

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(4R,cis)-1,1-Dimethylethyl-6-aminoethyl-2,2-dimethyl-1,3-dioxane-4-acetate

(4R)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Ezetimibe

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(4R)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(4S,5R)-2-(4-methoxy-phenyl)-3-N-BOC-4-phenyl-3, 5-oxazolidine carboxylic acid 500 g  | >98%

Clearsynth

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(4S,5R)-2-(4-methoxy-phenyl)-3-N-BOC-4-phenyl-3, 5-oxazolidine carboxylic acid

(4S,6S)-4H-Thieno[2,3-b]Thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide 500 g  | >98%

Clearsynth

(4R,6S)-4H-Thieno[2,3-b]thiopyran-4-ol, 5,6-dihydro-6-methyl-, 7,7-dioxide is an analog of topically-active carbonic anhydrase inhibitor MK-0507

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(4S,6S)-4H-Thieno[2,3-b]Thiopyran-4-ol-5,6-dihydro-6-methyl-7,7-dioxide

(4S,6S)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester 500 g  | >98%

Clearsynth

Building Blocks

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(4S,6S)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester

(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone 500 g  | >98%

Clearsynth

An impurity of Ezetimibe , an antihyperlipoproteinemic and cholesterol absorption inhibitor.

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(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone

(4S)-3-[(4E)-5-(4-fluorophenyl)pent-4-enoyl]-4-phenyl-1,3-oxazolidin-2-one 500 g  | >98%

Clearsynth

(4S)-3-[(4E)-5-(4-Fluorophenyl)-1-oxo-4-penten-1-yl]-4-phenyl-2-oxazolidinone is an impurity of Ezetimibe (E975000), which is an antihyperlipoproteinemic and a cholesterol absorption inhibitor.

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(4S)-3-[(4E)-5-(4-fluorophenyl)pent-4-enoyl]-4-phenyl-1,3-oxazolidin-2-one

(4S)-3-[5-(4-fluorophenyl)pentanoyl]-4-phenyl-1,3-oxazolidin-2-one 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Ezetimibe.

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(4S)-3-[5-(4-fluorophenyl)pentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanol 500 g  | >98%

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(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanol

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methoxy)(t-butyl)dimethyl)silane 500 g  | >98%

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(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methoxy)(t-butyl)dimethyl)silane

(5-PyriMidinecarboxylicacid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-(Methylthio)-,ethyl ester) 500 g  | >98%

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(5-PyriMidinecarboxylicacid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-(Methylthio)-,ethyl ester)

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester 500 g  | >98%

Clearsynth

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(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

(5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester 500 g  | >98%

Clearsynth

Intermediate in the preparation of Atorvastatin 10-Trans (Atorvastatin Impurity AT10)

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(5R)-6-Cyano-5-hydroxy-3-oxo-hexanoic Acid tert-Butyl Ester

(5S)-N,5-bis(4-fluorophenyl)-5-hydroxypentanamide 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Ezetimibe.

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(5S)-N,5-bis(4-fluorophenyl)-5-hydroxypentanamide

(6R,7R)-7-Amino-3-[(Z)-2-(4-methylthiazol-5-yl)ethenyl]-3-cephem-4-carboxylic Acid 500 g  | >98%

Clearsynth

Intermediate in the preparation of Cephalosporin antibiotics and derivatives.

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(6R,7R)-7-Amino-3-[(Z)-2-(4-methylthiazol-5-yl)ethenyl]-3-cephem-4-carboxylic Acid

(6S)-6-[5-(7-Bromo-9,9-difluoro-9Hfluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane-5-carboxylic acid 1,1-dimethylethyl ester 500 g  | >98%

Clearsynth

Ledipasvir Intermediate

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(6S)-6-[5-(7-Bromo-9,9-difluoro-9Hfluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane-5-carboxylic acid 1,1-dimethylethyl ester

(7E,9E)Ionylidene Acetaldehyde 500 g  | >98%

Clearsynth

Intermediate in the preparation of Retinoic Acid derivatives.

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(7E,9E)Ionylidene Acetaldehyde

(9E)-Erythromycin A Oxime 500 g  | >98%

Clearsynth

Metabolites

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(9E)-Erythromycin A Oxime

(aS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine 500 g  | >98%

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Impurities

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(aS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine

(Carbethoxymethylene)triphenylphosphorane 500 g  | >98%

Clearsynth

Fine Chemical

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(Carbethoxymethylene)triphenylphosphorane

(Chloromethyl)Dimethylisopropoxysilane 500 g  | >98%

Clearsynth

API Standard

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(Chloromethyl)Dimethylisopropoxysilane

(Cyanomethyl)triphenylphosphonium chloride 500 g  | >98%

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Synthetic Reagents

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(Cyanomethyl)triphenylphosphonium chloride

(Des-Pro-NHEt9)-Leuprolide 500 g  | >98%

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Drug Peptides

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(Des-Pro-NHEt9)-Leuprolide

(Dimethylamino)acetic acid 500 g  | >98%

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Fine Chemical

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(Dimethylamino)acetic acid

(E)-Tamoxifen 500 g  | >98%

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Impurities

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(E)-Tamoxifen

(E/Z)-Tamoxifen 500 g  | >98%

Clearsynth

Building Blocks

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(E/Z)-Tamoxifen

(N,N-didemethyl) 1-Hydroxy Sibutramine Hydrocholride 500 g  | >98%

Clearsynth

De(N,N-dimethyl) 1-Hydroxy Sibutramine Hydrocholride is an intermediate in the synthesis of De(N,N,3-trimethyl) Sibutramine Hydrocholride , an analogue of Sibutramine , a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.

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(N,N-didemethyl) 1-Hydroxy Sibutramine Hydrocholride

(R,R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane 500 g  | >98%

Clearsynth

Intermediate of Lurasidone

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(R,R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane

(R,R)-Empagliflozin 500 g  | >98%

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Impurities

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(R,R)-Empagliflozin

(R,R)-Palonosetron Hydrochloride 500 g  | >98%

Clearsynth

Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.

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(R,R)-Palonosetron Hydrochloride

(R,S)-2,2-Dimethyl-1,3-dioxolane-4-methanol 500 g  | >98%

Clearsynth

Fine Chemical

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(R,S)-2,2-Dimethyl-1,3-dioxolane-4-methanol

(R,S)-Iso Valganciclovir 500 g  | >98%

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Impurities

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(R,S)-Iso Valganciclovir

(R)-(-)-3-Aminopiperidine dihydrochloride 500 g  | >98%

Clearsynth

Fine Chemical

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(R)-(-)-3-Aminopiperidine dihydrochloride

(R)-(-)-3-Hydroxytetrahydrofuran 500 g  | >98%

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(R)-(-)-3-Hydroxytetrahydrofuran

(R)-(-)-Carvone 500 g  | >98%

Clearsynth

Impurities

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(R)-(-)-Carvone

(R)-(-)-Hydroxy Chloroquine Diphosphate 500 g  | >98%

Clearsynth

Impurity in commercial preparation of Chloroquine.

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(R)-(-)-Hydroxy Chloroquine Diphosphate

(R)-(-)-Ketoprofen 500 g  | >98%

Clearsynth

Anti-inflammatory; analgesic.

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(R)-(-)-Ketoprofen

(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, Unstable 500 g  | >98%

Clearsynth

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(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde, Unstable