AdipoGen Life Sciences

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AdipoGen Life Sciences develops and manufactures new products for the Life Science Research Market in the key areas of cancer, immunology, inflammation, metabolic syndrome (diabetes, obesity), stem cell biology, and neurodegeneration. The product portfolio consists of antibodies, proteins, ELISA Kits and innovative small molecules. The chemical portfolio includes, rare antibiotics, unique natural products, synthetic kinase modulators, fluorescent probes and much more.

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SANT-2 1 mg  | >95%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

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SANT-2 5 mg  | >95%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

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Saquayamycin B1 500 µg  | >98%

AdipoGen Life Sciences

Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1).

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Saquayamycin B1 1 mg  | >98%

AdipoGen Life Sciences

Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1).

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Saquayamycin B1 5 mg  | >98%

AdipoGen Life Sciences

Angucycline antibiotic. Antibacterial. Antitumor compound. Active against Gram-positive bacteria and P388 leukaemia cells. Farnesyl-protein transferase inhibitor. Inhibitor of nitric oxide synthase (NOS) (shown for Saquayamycin A1).

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Sarcophine 2 mg  | >97%

AdipoGen Life Sciences

Acetylcholine esterase and ATPase inhibitor. Ichthyotoxin. Tumorigenesis and JB6 cell transformation inhibitor.

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Sarcophine 10 mg  | >97%

AdipoGen Life Sciences

Acetylcholine esterase and ATPase inhibitor. Ichthyotoxin. Tumorigenesis and JB6 cell transformation inhibitor.

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Sauchinone 1 mg  | >98%

AdipoGen Life Sciences

Hepatoprotective antioxidant. Anti-inflammatory. Suppresses NF-kB p65 activity. Neuroprotective. Apoptosis inhibitor. Bone resorption/osteoclastogenesis inhibitor. Reduces ROS formation. Antiseptic. AMP-activated kinase (AMPK) activator. Akt phosphorylation inhibitor.

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Sauchinone 5 mg  | >98%

AdipoGen Life Sciences

Hepatoprotective antioxidant. Anti-inflammatory. Suppresses NF-kB p65 activity. Neuroprotective. Apoptosis inhibitor. Bone resorption/osteoclastogenesis inhibitor. Reduces ROS formation. Antiseptic. AMP-activated kinase (AMPK) activator. Akt phosphorylation inhibitor.

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SB202190 1 mg  | >97%

AdipoGen Life Sciences

Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer

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SB202190 5 mg  | >97%

AdipoGen Life Sciences

Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer

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SB202190 25 mg  | >97%

AdipoGen Life Sciences

Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer

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SB203580 1 mg  | >98%

AdipoGen Life Sciences

Cell permeable, specific p38 MAP kinase inhibitor. Binds to the ATP binding site of p38 MAP kinase. T cell proliferation inhibitor. IL-2 production inhibitor. SAPK/JNK inhibitor. COX-1 and -2 inhibitor. Raf-1 activator. Apoptosis enhancer. Antiproliferative. PDK1 inhibitor. Anti-inflammatory. Review. Enhances cardiomyogenesis of human embryonic stem cells (hESCs).

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SB203580 5 mg  | >98%

AdipoGen Life Sciences

Cell permeable, specific p38 MAP kinase inhibitor. Binds to the ATP binding site of p38 MAP kinase. T cell proliferation inhibitor. IL-2 production inhibitor. SAPK/JNK inhibitor. COX-1 and -2 inhibitor. Raf-1 activator. Apoptosis enhancer. Antiproliferative. PDK1 inhibitor. Anti-inflammatory. Review. Enhances cardiomyogenesis of human embryonic stem cells (hESCs).

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SB203580 25 mg  | >98%

AdipoGen Life Sciences

Cell permeable, specific p38 MAP kinase inhibitor. Binds to the ATP binding site of p38 MAP kinase. T cell proliferation inhibitor. IL-2 production inhibitor. SAPK/JNK inhibitor. COX-1 and -2 inhibitor. Raf-1 activator. Apoptosis enhancer. Antiproliferative. PDK1 inhibitor. Anti-inflammatory. Review. Enhances cardiomyogenesis of human embryonic stem cells (hESCs).

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SBD-F 5 mg  | >98%

AdipoGen Life Sciences

Fluorescent probe for thiols widely used in pre-column labeling of biological thiols for HPLC.

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SBD-F 25 mg  | >98%

AdipoGen Life Sciences

Fluorescent probe for thiols widely used in pre-column labeling of biological thiols for HPLC.

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SBD-F 250 mg  | >98%

AdipoGen Life Sciences

Fluorescent probe for thiols widely used in pre-column labeling of biological thiols for HPLC.

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Sceliphrolactam 1 mg  | >93%

AdipoGen Life Sciences

Unusual polyene antibiotic. Antifungal and antibacterial agent. Inhibits amphothericin B-resistant Candida albicans (MIC 4µg/ml).

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Sceliphrolactam 5 mg  | >93%

AdipoGen Life Sciences

Unusual polyene antibiotic. Antifungal and antibacterial agent. Inhibits amphothericin B-resistant Candida albicans (MIC 4µg/ml).

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Sceptrin . dihydrochloride 500 µg  | >97%

AdipoGen Life Sciences

Antibiotic. Inhibits the growth of several Gram-positive and Gram-negative bacteria. Binds to MreB inducing disruption of the bacterial cell wall. Competitive inhibitor of muscarinic acetylcholine receptors (mAChR). Cell motility inhibitor by specifically blocking contractility of the cell. Direct binding with monomeric actin disrupts the polymerization of actin into microfilaments necessary for cellular mechanical processes.

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Sclerotiorin 0.5 mg  | >97%

AdipoGen Life Sciences

Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal.

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Sclerotiorin 1 mg  | >97%

AdipoGen Life Sciences

Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal.

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Sclerotiorin 5 mg  | >97%

AdipoGen Life Sciences

Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal.

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Secalonic acid F 1 mg  | >95%

AdipoGen Life Sciences

Mycotoxin. Common contaminant in corn and other grains. Hybrid dimer of Blennolide A and B. Cytotoxic anticancer compound. Reported to induce apoptosis by modulating RhoGDI 2 levels in HL60 cells. Protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50=9.6µM). PTP1B is thought to function as a negative regulator of insulin and leptin signal transduction and therefore being […]

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Sekikaic acid 1 mg  | >96%

AdipoGen Life Sciences

Antioxidant. Reactive oxygen species (ROS) scavenger. Specific ligand of the coactivator CBP/p300, binding to the GACKIX domain. Efficiently inhibits binding of activators at two binding sites. Antibiotic. Potent antibacterial compound. Antifungal on selected fungi species. Antiviral agent. Interferes with the viral replication of selected respiratory syncytial virus. Competitive alpha-glucosidase and non-competitive beta-glucosidase inhibitor. Shows moderate […]

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Selamectin 25 mg  | >99%

AdipoGen Life Sciences

Avermectin derivative prepared by hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of parasites that acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of […]

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Selamectin 100 mg  | >99%

AdipoGen Life Sciences

Avermectin derivative prepared by hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of parasites that acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of […]

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Sericic acid 5 mg  | >95%

AdipoGen Life Sciences

Anti-inflammatory. Antibacterial. Antifungal. Haemolytic agent. Weak phosphodiesterase 4 (PDE4) inhibitor.. Antioxidant.

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Sericic acid 25 mg  | >95%

AdipoGen Life Sciences

Anti-inflammatory. Antibacterial. Antifungal. Haemolytic agent. Weak phosphodiesterase 4 (PDE4) inhibitor.. Antioxidant.

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Serratol 5 mg  | >95%

AdipoGen Life Sciences

Component of the frankincense essential oil. Potent activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. More powerful TRPV3 agonist than incensol (Prod. No. AG-CN2-0482) and incensol acetate (Prod. No. AG-CN2-0484). Anti-protozoal agent.

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Setomimycin [Setomimicin] 1 mg  | >97%

AdipoGen Life Sciences

9,9`-Bianthryl polyketide derivative. Antibiotic. Active against Gram-positive bacteria including mycobacteria. Bacterial cell wall synthesis inhibitor. Antitumor compound.

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Setomimycin [Setomimicin] 5 mg  | >97%

AdipoGen Life Sciences

9,9`-Bianthryl polyketide derivative. Antibiotic. Active against Gram-positive bacteria including mycobacteria. Bacterial cell wall synthesis inhibitor. Antitumor compound.

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Shikonin 10 mg  | >98%

AdipoGen Life Sciences

Anticancer compound. Inhibits TNF-alpha-induced and B-16 melanoma-induced angiogenesis. Induces apoptosis and RIP1- and RIP3-dependent necroptosis in several cancer cells. Circumvents cancer antidrug resistance through the necroptosis pathway. Proteasome inhibitor. Autophagy inducer. Topoisomerase I inhibitor. Inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (PKM2). Anti-inflammatory compound. Inhibits leukocyte migration, downregulates chemokine receptor expression, […]

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Shikonin 50 mg  | >98%

AdipoGen Life Sciences

Anticancer compound. Inhibits TNF-alpha-induced and B-16 melanoma-induced angiogenesis. Induces apoptosis and RIP1- and RIP3-dependent necroptosis in several cancer cells. Circumvents cancer antidrug resistance through the necroptosis pathway. Proteasome inhibitor. Autophagy inducer. Topoisomerase I inhibitor. Inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (PKM2). Anti-inflammatory compound. Inhibits leukocyte migration, downregulates chemokine receptor expression, […]

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Shz-1 1 mg  | >95%

AdipoGen Life Sciences

Enhancer of myocardial regenerative repair by stem cells. Potent inducer of Nkx2.5 and a subset of other cardiac markers, including myocardin, and sarcomeric-tropomyosin (SalphaTM) in a variety of different stem/progenitor cells.

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Shz-1 5 mg  | >95%

AdipoGen Life Sciences

Enhancer of myocardial regenerative repair by stem cells. Potent inducer of Nkx2.5 and a subset of other cardiac markers, including myocardin, and sarcomeric-tropomyosin (SalphaTM) in a variety of different stem/progenitor cells.

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Siamycin I 250 µg  | >85%

AdipoGen Life Sciences

Antibiotic. Lariat peptide antiviral. Anti-HIV and anti-HSV (Herpes simplex virus) agent. Fsr quorum sensing inhibitor. Calmodulin-activated myosin light chain kinase (MLCK) inhibitor.

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Siamycin I 1 mg  | >85%

AdipoGen Life Sciences

Antibiotic. Lariat peptide antiviral. Anti-HIV and anti-HSV (Herpes simplex virus) agent. Fsr quorum sensing inhibitor. Calmodulin-activated myosin light chain kinase (MLCK) inhibitor.

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Sildenafil citrate 50 mg  | >98%

AdipoGen Life Sciences

Potent cGMP-specific phosphodiesterase inhibitor that is highly selective for PDE5. It inhibits PDE5 activity in isolated rabbit platelets with an IC50 value of 3.6nM (3nM in human corpus cavernosum) compared to inhibition of PDE1 and PDE3 activities (IC50s = 0.26 and 65µM, respectively). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range […]

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Sildenafil citrate 250 mg  | >98%

AdipoGen Life Sciences

Potent cGMP-specific phosphodiesterase inhibitor that is highly selective for PDE5. It inhibits PDE5 activity in isolated rabbit platelets with an IC50 value of 3.6nM (3nM in human corpus cavernosum) compared to inhibition of PDE1 and PDE3 activities (IC50s = 0.26 and 65µM, respectively). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range […]

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Silthiopham 25 mg  | >98%

AdipoGen Life Sciences

Amide fungicide. Interferes with fungal respiration by inhibition of ATP-Production in mitochondrias. Compound can be used as analytical reference material.

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Simetone 25 mg  | >98%

AdipoGen Life Sciences

Triazine herbicide. Mode of action through inhibition of photosynthesis at photosystem II. Compound can be used as analytical reference material.

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Simocyclinone D8 1 mg  | >97%

AdipoGen Life Sciences

Antibiotic. Bacterial DNA gyrase inhibitor: Staphylococcus aureus (IC50= 1.45µM), E. coli (IC50= 0.41µM). Human topoisomerase II (Topo II) inhibitor (IC50= 100µM). Antibacterial (Gram-positive). Antitumor compound.

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Simocyclinone D8 5 mg  | >97%

AdipoGen Life Sciences

Antibiotic. Bacterial DNA gyrase inhibitor: Staphylococcus aureus (IC50= 1.45µM), E. coli (IC50= 0.41µM). Human topoisomerase II (Topo II) inhibitor (IC50= 100µM). Antibacterial (Gram-positive). Antitumor compound.

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Simvastatin 10 mg  | >98%

AdipoGen Life Sciences

Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051 http://www.adipogen.com/ag-cn2-0051/lovastatin.html ). Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Smooth muscle cell proliferation inhibitor. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Proteasome modulator. […]

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Simvastatin 50 mg  | >98%

AdipoGen Life Sciences

Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051 http://www.adipogen.com/ag-cn2-0051/lovastatin.html ). Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Smooth muscle cell proliferation inhibitor. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Proteasome modulator. […]

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SIN-1 chloride 10 mg  | >98%

AdipoGen Life Sciences

Nitric oxide (NO) donor. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite. Platelet aggregation inhibitor. Guanylyl cyclase activator. Cytotoxic. Positive ionotropic. Vasodilator.

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