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SAG Analog (LowTox) 1 mg  | >98%

AdipoGen Life Sciences

Cell permeable low toxicity Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Potent activator of VEGF expression in vitro.

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22-NHC . hydrochloride 1 mg  | >98%

AdipoGen Life Sciences

Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .

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22-NHC . hydrochloride 5 mg  | >98%

AdipoGen Life Sciences

Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .

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6-ECDCA 5 mg  | >95%

AdipoGen Life Sciences

Potent and selective FXR agonist (EC50= 99nM). Induces SHP in HSCs to suppress TIMP-1 expression. Apoptosis inducer. Protects against liver fibrosis development in rat in vivo. Displays anticholeretic activity in rat in vivo. Promotes preadipocyte differentiation. Regulates adipogenesis and insulin signaling in vivo. Inhibits vascular smooth muscle cell inflammation and migration.

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IHR-NAc 5 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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IHR-NAc 1 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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IHR-1 5 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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IHR-1 1 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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7-Azido-4-methylcoumarin 5 mg  | >98%

AdipoGen Life Sciences

Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). […]

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