22-NHC . hydrochloride
Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .
| Catalog Number | AG-CR1-3523-M005 |
| Alternative Name(s) | 22-Azacholesterol; (3beta)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol |
| Research Area | Biochemicals, Cancer, Immunology, Stem Cell Research |
| Molecular Formula | C26H45NO . HCl |
| CAS# | 360068-87-7 or 3915-24-0 (free base) |
| Purity | >98% |
| Inchi | InChI=1S/C26H45NO.ClH/c1-17(2)12-15-27-18(3)22-8-9-23-21-7-6-19-16-20(28)10-13-25(19,4)24(21)11-14-26(22,23)5;/h6,17-18,20-24,27-28H,7-16H2,1-5H3;1H/t18?,20-,21-,22+,23-,24-,25-,26+;/m0./s1 |
| Inchi Key | GDMMRLCQKPSXQG-USNJAYOWSA-N |
| SMILES | [Cl-].[H][C@@]12CC[C@H]([C@H](C)[NH2+]CCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3523/22-nhc-hydrochloride.html |