Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

VX-11e (VTX-11e, Vertex-11e) is a potent, selective, and orally bioavailable ERK inhibitor with IC50 of 17 nM (ERK1) and 15 nM (ERK2), over 200-fold selective over other kinases tested.

CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.

BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.

Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).

Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).