Pimitespib (TAS-116)

Pimitespib (TAS-116) is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L).

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Trivial name	N/A
Catalog Number	S7716
Molecular Formula	C25H26N8O
CAS#	1260533-36-5
Inchi	InChI=1S/C25H26N8O/c1-5-16-10-17(24(26)34)6-7-20(16)33-25-22(23(30-33)15(2)3)21(8-9-27-25)32-13-19(28-14-32)18-11-29-31(4)12-18/h6-15H,5H2,1-4H3,(H2,26,34)
Inchi Key	NVVPMZUGELHVMH-UHFFFAOYSA-N
SMILES	CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C
Size	5mg
Supplier Page	http://www.selleckchem.com/products/tas-116.html
Additional Information	https://file.selleck.cn/downloads/struct/s7716-chemical-structure-tas-116.gif