IHR-NAc
Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
| Catalog Number | AG-CR1-3527-M005 |
| Alternative Name(s) | 5-Acetamido-2-chloro-N-[4-(2,5-dichlorobenzamido)phenyl]benzamide |
| Research Area | Biochemicals, Cancer |
| Molecular Formula | C22H16Cl3N3O3 |
| Purity | >98% |
| Inchi | InChI=1S/C22H16Cl3N3O3/c1-12(29)26-16-7-9-20(25)18(11-16)22(31)28-15-5-3-14(4-6-15)27-21(30)17-10-13(23)2-8-19(17)24/h2-11H,1H3,(H,26,29)(H,27,30)(H,28,31) |
| Inchi Key | KEKPTYABAFCFOT-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=CC=C(Cl)C(=C1)C(=O)NC1=CC=C(NC(=O)C2=C(Cl)C=CC(Cl)=C2)C=C1 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3527/ihr-nac.html |