Ac-Arg-Leu-Arg-AMC
Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. It is cleaved exclusively at the amide R-AMC bond to release fluorescent product. Shows low Km and high specific activity. Excitation: 380nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
| Catalog Number | AG-CP3-0013-M005 |
| Alternative Name(s) | Ac-RLR-AMC . TFA; Proteasome Substrate |
| Research Area | Biochemicals, Cancer, Immunology |
| Molecular Formula | C30H46N10O6 . C2HF3O2 |
| CAS# | 929903-87-7 (free base) |
| Purity | >97% |
| Inchi | InChI=1S/C30H46N10O6.C2HF3O2/c1-16(2)13-23(40-27(44)21(37-18(4)41)7-5-11-35-29(31)32)28(45)39-22(8-6-12-36-30(33)34)26(43)38-19-9-10-20-17(3)14-25(42)46-24(20)15-19;3-2(4,5)1(6)7/h9-10,14-16,21-23H,5-8,11-13H2,1-4H3,(H,37,41)(H,38,43)(H,39,45)(H,40,44)(H4,31,32,35)(H4,33,34,36);(H,6,7)/t21-,22-,23-;/m0./s1 |
| Inchi Key | CEEMPRHZPRGAAK-RGRVRPFLSA-N |
| SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC1=CC2=C(C=C1)C(C)=CC(=O)O2 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cp3-0013/ac-arg-leu-arg-amc.html |