MLN4924 Solution
Potent, selective and cell-permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE). By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis.
| Catalog Number | AG-CS1-0103-M001 |
| Alternative Name(s) | Pevonedistat; Nedd8 E1 Activating Enzyme Inhibitor |
| Research Area | Apoptosis, Biochemicals, Cancer |
| Molecular Formula | C21H25N5O4S |
| CAS# | 905579-51-3 |
| Purity | >99% |
| Inchi | InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)-(H,23,24,25)/t14-,15+,18-,19-/m0/s1 |
| Inchi Key | MPUQHZXIXSTTDU-QXGSTGNESA-N |
| SMILES | [H][C@@]1(C[C@H](O)[C@H](COS(N)(=O)=O)C1)N1C=CC2=C(N[C@H]3CCC4=CC=CC=C34)N=CN=C12 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cs1-0103/mln4924-nae-inhibitor-solution.html |