Bafilomycin B1
Macrolide antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antitrypanosomal and antileishmanial compound. Phytotoxic. Influences the cell wall biosynthesis of Asp. niger.
| Catalog Number | BVT-0004-M005 |
| Alternative Name(s) | Setamycin; BRN4640118 |
| Research Area | Antibiotic, Autophagy, Immunology, Natural Products |
| Molecular Formula | C₄₄H₆₅NO₁₃ |
| CAS# | 88899-56-3 |
| Purity | >97% |
| Inchi | InChI=1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12-,18-17+,24-13+,25-20+,34-21-/t26-,27-,28+,29+,30?,33+,35-,39+,40-,41-,42-,44-/m1/s1 |
| Inchi Key | KFUFLYSBMNNJTF-APLCIVFZSA-N |
| SMILES | [H][C@@]1(OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@@H](O)[C@@H](C)CC(C)=CC=C/[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC(=O)C=CC(=O)NC2=C(O)CCC2=O)[C@H](C)C(O1)C(C)C |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/bvt-0004/bafilomycin-b1.html |