Fostriecin

Antibiotic. Anticancer compound. Antifungal. Catalytic inhibitor of topoisomerase II (IC50 = 40 µM). Potent protein phosphatase 2A (PP2A) (IC50 = 1.5 nM) and 4 (PP4) (IC50 = 3 nM) inhibitor. Weak protein phosphatase type 1 (PP1) inhibitor (IC50=131µM). No apparent inhibition on PP2B. Mitotic entry checkpoint inhibitor. Mediates cell cycle arrest at G2-M-phase. Ischemia protective. The PP2A binding site is different from that of okadaic acid

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Catalog Number	AG-CN2-0057-C010
Alternative Name(s)	Phosphotrienin; CI-920; CL-1565A; NSC-339638; PD 110,161; Pyranone phosphate
Research Area	Antibiotic, Biochemicals, Cancer, Inflammation, Natural Products
Molecular Formula	C19H26O9PNa
CAS#	87860-39-7
Purity	>98%
Inchi	InChI=1/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1/b3-2-,6-4+,8-5-,12-11+;/t15-,16+,17+,19+;/m0./s1
Inchi Key	XBUIKNRVGYFSHL-CZYWAGOEBB
SMILES	[Na+].C[C@@](O)(C=C[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)C=C/C=CC=CCO)OP(O)([O-])=O
Size	10 µg
Supplier Page	http://www.adipogen.com/ag-cn2-0057/fostriecin.html