RO-3306
Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M . Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards.
| Catalog Number | AG-CR1-3515-M005 |
| Alternative Name(s) | (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one |
| Research Area | Apoptosis, Biochemicals, Cancer, Cell Death |
| Molecular Formula | C18H13N3OS2 |
| CAS# | 872573-93-8 |
| Purity | >95% |
| Inchi | InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10- |
| Inchi Key | XOLMRFUGOINFDQ-YBEGLDIGSA-N |
| SMILES | O=C1N=C(NCC2=CC=CS2)SC1=C/C1=CC2=C(C=C1)N=CC=C2 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3515/ro-3306.html |