cGAMP . 2Na [STING Ligand]

Potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-beta. First cyclic nucleotide in metazoa. Plays a role in bacterial chemotaxis and colonization.

Price Not Available 500 µg cGAMP . 2Na [STING Ligand] Supplier Page

Catalog Number	AG-CR1-3588-C500
Alternative Name(s)	cyclic (adenosine monophosphate-guanosine monophosphate); cyclic GMP-AMP; c-(GpAp); 3',3'-cGAMP
Research Area	Biochemicals, Immunology, Inflammation
Molecular Formula	C20H24N10O13P2 . 2Na
CAS#	849214-04-6 (free acid)
Purity	>98%
Inchi	InChI=1S/C20H24N10O13P2.2Na/c21-14-8-15(24-3-23-14)29(4-25-8)18-10(31)12-6(40-18)1-38-45(36,37)43-13-7(2-39-44(34,35)42-12)41-19(11(13)32)30-5-26-9-16(30)27-20(22)28-17(9)33;;/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33);;/q;2*+1/p-2/t6-,7?,10-,11-,12-,13-,18?,19-;;/m0./s1
Inchi Key	MFPHQIYDBUVTRL-HBMYJXICSA-L
SMILES	[Na+].[Na+].NC1=NC2=C(N=CN2C2O[C@H]3CO[P@@]([O-])(=O)OC4C(COP([O-])(=O)OC3C2O)O[C@@H](C4O)N2C=NC3=C(N)N=CN=C23)C(=O)N1
Size	500 µg
Supplier Page	http://www.adipogen.com/ag-cr1-3588/cgamp.html