cGAMP . 2Na [STING Ligand]

Potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-beta. First cyclic nucleotide in metazoa. Plays a role in bacterial chemotaxis and colonization.

Price Not Available 100 µg cGAMP . 2Na [STING Ligand] Supplier Page
Catalog Number AG-CR1-3588-C100
Alternative Name(s) cyclic (adenosine monophosphate-guanosine monophosphate); cyclic GMP-AMP; c-(GpAp); 3',3'-cGAMP
Research Area Biochemicals, Immunology, Inflammation
Molecular Formula C₂₀H₂₄N₁₀O₁₃P₂ . ₂Na
CAS# 849214-04-6 (free acid)
Purity >98%
Inchi InChI=1S/C20H24N10O13P2.2Na/c21-14-8-15(24-3-23-14)29(4-25-8)18-10(31)12-6(40-18)1-38-45(36,37)43-13-7(2-39-44(34,35)42-12)41-19(11(13)32)30-5-26-9-16(30)27-20(22)28-17(9)33;;/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33);;/q;2*+1/p-2/t6-,7?,10-,11-,12-,13-,18?,19-;;/m0./s1
Inchi Key MFPHQIYDBUVTRL-HBMYJXICSA-L
SMILES [Na+].[Na+].NC1=NC2=C(N=CN2C2O[C@H]3CO[P@@]([O-])(=O)OC4C(COP([O-])(=O)OC3C2O)O[C@@H](C4O)N2C=NC3=C(N)N=CN=C23)C(=O)N1
Size 100 µg
Supplier Page http://www.adipogen.com/ag-cr1-3588/cgamp.html