10Z-Hymenialdisine
Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor.
| Catalog Number | AG-CN2-0067-M001 |
| Alternative Name(s) | Hymenialdisine; 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one |
| Research Area | Cancer, Inflammation, Natural Products |
| Molecular Formula | C11H10BrN5O2 |
| CAS# | 82005-12-7 |
| Purity | >97% |
| Inchi | InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)/b7-4- |
| Inchi Key | ATBAETXFFCOZOY-DAXSKMNVSA-N |
| SMILES | NC1=NC(=O)C(N1)=C1/CCNC(=O)C2=C1C=C(Br)N2 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0067/10z-hymenialdisine.html |