Latrunculin B
Cell permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes actin filaments (F-actin). Less potent than Latrunculin A (Prod. No. AG-CN2-0027 http://www.adipogen.com/ag-cn2-0027/latrunculin-a.html ). May have fewer unwanted effects than latrunculin A and may be preferred for short-term studies. Acts via a different mechanism than cytochalasins.
| Catalog Number | AG-CN2-0031-M001 |
| Alternative Name(s) | LAT-B; NSC 339663 |
| Research Area | Apoptosis, Cancer, Cell Death, Natural Products |
| Molecular Formula | C20H29NO5S |
| CAS# | 76343-94-7 |
| Purity | >96% |
| Inchi | InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1 |
| Inchi Key | NSHPHXHGRHSMIK-JRIKCGFMSA-N |
| SMILES | C[C@@H](CC[C@@H](O[C@]([C@@]1([H])NC(SC1)=O)(O)C2)C[C@H]2O3)/C=CCC/C(C)=CC3=O |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0031/latrunculin-b.html |