Regorafenib [BAY 73-4506]
Orally bioavailable potent antitumor, antiangiogenic, antiproliferative and antineoplastic agent. Multi-target kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRbeta, Kit, RET and Raf-1 with IC50 values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively.
| Catalog Number | AG-CR1-3623-M025 |
| Alternative Name(s) | BAY 73-4506; Fluoro-Sorafenib |
| Research Area | Biochemicals, Cancer |
| Molecular Formula | C21H15ClF4N4O3 |
| CAS# | 755037-03-7 |
| Purity | >98% |
| Inchi | InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32) |
| Inchi Key | FNHKPVJBJVTLMP-UHFFFAOYSA-N |
| SMILES | CNC(=O)C1=CC(OC2=CC(F)=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=CC=N1 |
| Size | 25 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3623/regorafenib.html |