Staurosporine
Antibiotic. Antifungal and anti-yeast activity. Inhibits platelet aggregation induced by collagen or ADP. Has no effect on thrombin-induced platelet aggregation. Potent, cell permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits protein kinase A, CaM kinase, myosin light chain kinase, protein kinase C, protein kinase G, CDK1/cyclin B, CDK2/cyclin A, CDK4/cyclin D, CDK5/p25, GSK-3beta and Pim-1 kinase. Key apoptosis inducer. Topoisomerase II (Topo II) inhibitor.
| Catalog Number | AG-CN2-0022-M001 |
| Alternative Name(s) | Antibiotic AM2282; Antibiotic 230; CCRIS 3272 |
| Research Area | Antibiotic, Apoptosis, Cancer, Cell Death, Immunology, Inflammation, Natural Products |
| Molecular Formula | C28H26N4O3 |
| CAS# | 62996-74-1 |
| Purity | >98% |
| Inchi | 1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 |
| Inchi Key | HKSZLNNOFSGOKW-FYTWVXJKSA-N |
| SMILES | [H][C@]12C[C@@H](NC)[C@@H](OC)[C@](C)(O1)N1C3=C(C=CC=C3)C3=C4CNC(=O)C4=C4C5=C(C=CC=C5)N2C4=C13 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0022/staurosporine.html |