Cucurbitacin B
Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation. Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties. Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell lines. Shown to inhibit STAT 3 phosphorylation and expression levels and blocks JAK2 activity, as well as the transcriptional activity of HIF1alpha and NF-kappaB. Antioxidant. Serves as an ecdysteroid receptor antagonist in Drosophila.
| Catalog Number | AG-CN2-0472-M001 |
| Alternative Name(s) | Cuc B; 1,2-Dihydro-alpha-elaterin; Amarine; NSC 49451; NSC 144154 |
| Research Area | Apoptosis, Cancer, Cell Death, Immunology, Inflammation, Natural Products, Neurodegenerative Disease |
| Molecular Formula | C32H46O8 |
| CAS# | 6199-67-3 |
| Purity | >98% |
| Inchi | InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1 |
| Inchi Key | IXQKXEUSCPEQRD-DKRGWESNSA-N |
| SMILES | [H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)C=CC(C)(C)OC(C)=O |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0472/cucurbitacin-b.html |