Secalonic acid F
Mycotoxin. Common contaminant in corn and other grains. Hybrid dimer of Blennolide A and B. Cytotoxic anticancer compound. Reported to induce apoptosis by modulating RhoGDI 2 levels in HL60 cells. Protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50=9.6µM). PTP1B is thought to function as a negative regulator of insulin and leptin signal transduction and therefore being involved in type 2 diabetes and obesity pathology. Antimicrobial agent against Bacillus megaterium. Allelopathic agent.
| Catalog Number | AG-CN2-0488-M001 |
| Alternative Name(s) | SAF; Ergochrome BE |
| Research Area | Cancer, Natural Products |
| Molecular Formula | C32H30O14 |
| CAS# | 60687-07-2 |
| Purity | >95% |
| Inchi | InChI=1S/C32H30O14/c1-11-9-15(33)21-25(37)19-17(45-31(21,27(11)39)29(41)43-3)7-5-13(23(19)35)14-6-8-18-20(24(14)36)26(38)22-16(34)10-12(2)28(40)32(22,46-18)30(42)44-4/h5-8,11-12,27-28,33-36,39-40H,9-10H2,1-4H3/t11-,12-,27-,28+,31?,32?/m0/s1 |
| Inchi Key | DRYDKQOPVBDZMQ-WVMRRKDFSA-N |
| SMILES | OC1=C2[C@](OC3=CC=C(C4=C(O)C(C(C5=C(O)C[C@H](C)[C@H](O)[C@]5(C(OC)=O)O6)=O)=C6C=C4)C(O)=C3C2=O)(C(OC)=O)[C@H](O)[C@@H](C)C1 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0488/secalonic-acid-f.html |