Trichostatin A
Antibiotic. Antifungal. Antiprotozoal. Potent and reversible, cell permeable inhibitor of histone deacetylase (HDAC). Immunosuppressive. Anticancer compound. Antifibrogenic. Apoptosis inducer. Induces cell growth arrest at both G1 and G2/M phases. Enhances the efficacy of anticancer agents that target DNA. Inactivates mitotic spindle checkpoint. Smooth muscle cell proliferation inhibitor. Telomerase inhibitor. Downregulates DNA methyltransferase DNMT1 and affects DNA methylation. Anti-inflammatory. Inhibits osteoclastogenesis and bone resorption. Promotes either self-renewal or differentiation of embryonic stem cells.
| Catalog Number | AG-CN2-0108-M005 |
| Alternative Name(s) | TSA; A300; R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide |
| Research Area | Antibiotic, Apoptosis, Bone Research, Cancer, Cell Death, Immunology, Inflammation, Natural Products, Stem Cell Research |
| Molecular Formula | C17H22N2O3 |
| CAS# | 58880-19-6 |
| Purity | >95% |
| Inchi | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
| Inchi Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| SMILES | C[C@H](C=C(/C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0108/trichostatin-a.html |