Paxilline
Tremorgenic. Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels. Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)). Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor. Liver X receptor (LXRalpha and LXRbeta; NR1H3 and NR1H2) agonist in biochemical and in vitro cell-based assays. Anticonvulsant. Apoptosis enhancer. Can sensitize various glioma cells to TRAIL-mediated apoptosis. Shown to protect neuronal cells against glutamate-induced cell death.
| Catalog Number | AG-CN2-0167-M001 |
| Alternative Name(s) | BRN 5317894; NSC 658707 |
| Research Area | Antibiotic, Apoptosis, Natural Products, Neurobiology |
| Molecular Formula | C27H33NO4 |
| CAS# | 57186-25-1 |
| Purity | >95% |
| Inchi | InChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1 |
| Inchi Key | ACNHBCIZLNNLRS-UBGQALKQSA-N |
| SMILES | [H][C@]12CC3=C(NC4=C3C=CC=C4)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H](C(=O)C=C3[C@]1(O)CC2)C(C)(C)O |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0167/paxilline.html |