Paprotrain
Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation. Moderate DYRK1A inhibitor (IC50= 5.5 µM). Lead compound.
| Catalog Number | AG-CR1-3504-M001 |
| Alternative Name(s) | (Z)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile |
| Research Area | Biochemicals, Cancer, Neurodegenerative Disease |
| Molecular Formula | C16H11N3 |
| CAS# | 57046-73-8 |
| Purity | >98% |
| Inchi | InChI=1S/C16H11N3/c17-9-13(8-12-4-3-7-18-10-12)15-11-19-16-6-2-1-5-14(15)16/h1-8,10-11,19H/b13-8+ |
| Inchi Key | YMYYQRZCCKBFBE-MDWZMJQESA-N |
| SMILES | [H]C(=C(C#N)C1=CNC2=C1C=CC=C2)C1=CN=CC=C1 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3504/paprotrain.html |