Umbellulone
Offensive principle of the so-called “headache tree”. Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine.
| Catalog Number | AG-CN2-0085-M010 |
| Alternative Name(s) | (-)-Umbellulone; Umbellol; NSC 22046; BRN 2042730; Oreodaphnol; 3-Thujen-2-one |
| Research Area | Biochemicals, Inflammation, Natural Products, Neurobiology |
| Molecular Formula | C10H14O |
| CAS# | 546-78-1 |
| Purity | >98% |
| Inchi | InChI=1S/C10H14O/c1-6(2)10-5-8(10)7(3)4-9(10)11/h4,6,8H,5H2,1-3H3 |
| Inchi Key | LTTVJAQLCIHAFV-UHFFFAOYSA-N |
| SMILES | CC(C)C12CC1C(C)=CC2=O |
| Size | 10 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0085/umbellulone.html |