Rapamycin

Antibiotic. Antibacterial and antifungal properties. Forms a complex with FKBP12 and inhibits the mammalian target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an alternative to calcineurin inhibitors. Restricts the proliferation of smooth-muscle cells by blocking cell cycle progression at the G1/S transition. Anti-proliferative. Antitumor compound. Apoptosis enhancer. Activator of autophagy both in vitro and in vivo. Anti-HIV and anti-aging compound. Neuroprotective. Suppressor for self-renewal and vascular differentiation potential in hemangioma stem cells.

Price Not Available 5 mg Rapamycin Supplier Page
Catalog Number AG-CN2-0025-M005
Alternative Name(s) Sirolimus; Rapamune; NSC 226080; Antibiotic AY-22989; WY-090217; RAPA; SILA 9268A; CCRIS 9024
Research Area Antibiotic, Apoptosis, Autophagy, Cancer, Cell Death, Immunology, Inflammation, Natural Products, Neurodegenerative Disease, Stem Cell Research
Molecular Formula C51H79NO13
CAS# 53123-88-9
Purity >98%
Inchi 1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32?,33-,34-,36-,37+,38-,39+,40-,42+,43+,44-,46-,47+,51+/m1/s1
Inchi Key QFJCIRLUMZQUOT-KIHCOMIKSA-N
SMILES [H][C@@]1(C[C@@H](C)[C@@H]2CC(=O)C(C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C(C)[C@H](C[C@@]3([H])CC[C@@H](C)[C@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](O)[C@@H](C1)OC
Size 5 mg
Supplier Page http://www.adipogen.com/ag-cn2-0025/rapamycin.html