6-ECDCA
Potent and selective FXR agonist (EC50= 99nM). Induces SHP in HSCs to suppress TIMP-1 expression. Apoptosis inducer. Protects against liver fibrosis development in rat in vivo. Displays anticholeretic activity in rat in vivo. Promotes preadipocyte differentiation. Regulates adipogenesis and insulin signaling in vivo. Inhibits vascular smooth muscle cell inflammation and migration.
| Catalog Number | AG-CR1-3560-M005 |
| Alternative Name(s) | 6alpha-Ethyl-chenodeoxycholic acid; 6-alpha-ECDC; Obeticholic acid; INT-747 |
| Research Area | Biochemicals, Immunology, Inflammation, Metabolism |
| Molecular Formula | C26H44O4 |
| CAS# | 459789-99-2 |
| Purity | >95% |
| Inchi | 1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19?,20?,21+,23?,24-,25-,26-/m1/s1 |
| Inchi Key | ZXERDUOLZKYMJM-AMGBFIHRSA-N |
| SMILES | [H][C@@]12C[C@H](O)CC[C@]1(C)C1CC[C@]3(C)[C@H](CCC3C1[C@H](O)[C@@H]2CC)[C@H](C)CCC(O)=O |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3560/6-ecdca.html |