Necrostatin-1
Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Cardioprotective and neuroprotective.
| Catalog Number | AG-CR1-2900-M025 |
| Alternative Name(s) | Nec-1; MTH-Trp; MTH-DL-Tryptophan; Methyl-thiohydantoin DL-tryptophan; 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
| Research Area | Autophagy, Biochemicals, Cancer, Cell Death, Inflammation, Metabolism, Necrosis, Neurodegenerative Disease |
| Molecular Formula | C13H13N3OS |
| CAS# | 4311-88-0 |
| Purity | >98% |
| Inchi | InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) |
| Inchi Key | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
| SMILES | CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O |
| Size | 25 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-2900/necrostatin-1.html |