OCH
Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 (IL-4) secretion and weaker interferon-gamma (IFN-gamma) secretion than alpha-GalCer both in vitro and in vivo. Inducer of interleukin-10 (IL-10) and suppressor of diabetes. Shown to prevent experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of multiple sclerosis. Has beneficial effects on type I diabetes in NOD mice. Suppressor of collagen-induced arthritis. Might be useful for immunotherapy of transplant rejection.
| Catalog Number | AG-CR1-3593-C250 |
| Alternative Name(s) | (2S,3S,4R)-1-O-(alpha-D-Galactopyranosyl)-N-tetracosanoyl-2-amino-1,3,4-nonanetriol) |
| Research Area | Biochemicals, Cancer, Immunology, Inflammation, Metabolism |
| Molecular Formula | C39H77NO9 |
| CAS# | 383187-82-4 |
| Purity | >95% |
| Inchi | InChI=1S/C39H77NO9/c1-3-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-26-28-34(43)40-31(35(44)32(42)27-25-6-4-2)30-48-39-38(47)37(46)36(45)33(29-41)49-39/h31-33,35-39,41-42,44-47H,3-30H2,1-2H3,(H,40,43)/t31-,32+,33+,35-,36-,37-,38+,39-/m0/s1 |
| Inchi Key | MPKIDHIOYNMFES-CLTBVUQJSA-N |
| SMILES | CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](COC1OC(CO)C(O)C(O)C1O)C(O)[C@H](O)CCCCC |
| Size | 250 µg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3593/och.html |