Convulxin
Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors. Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor gamma-chain and activates p72SYK that is critical for downstream activation of platelets. Causes cardiovascular and respiratory disturbances. Prostaglandins are strong inhibitors of convulxin-induced aggregation. Heterodimeric C-type lectin. Disulfide linked heterodimer consisting of homologous alpha and beta chains. The heterodimers are additionally linked by disulfide bridges to form cyclic alpha(4)beta(4)heterotetramers.
Catalog Number | AG-CN2-0465-C050 |
Alternative Name(s) | CVX |
Research Area | Immunology, Natural Products |
CAS# | 37206-04-5 |
Size | 50 µg |
Supplier Page | http://www.adipogen.com/ag-cn2-0465/convulxin.html |