Celastrol
Anti-obesity agent. Potent leptin sensitizer. Antioxidant. Potent lipid peroxidation inhibitor. NADPH oxidases (NOX1, 2, 4 and 5) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. HSP90 inhibitor and HSP70 inducer. Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways. Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1alpha pathway. Topoisomerase II inhibitor. 20S proteasome chymotrypsin-like activity inhibitor. Potential antiviral and anti-Alzheimer’s agent.
| Catalog Number | AG-CN2-0460-M010 |
| Alternative Name(s) | Tripterine; NSC 70931 |
| Research Area | Apoptosis, Autophagy, Biochemicals, Cancer, Cell Death, Inflammation, Metabolism, Natural Products, Neurodegenerative Disease, Obesity |
| Molecular Formula | C29H38O4 |
| CAS# | 34157-83-0 |
| Purity | >98% |
| Inchi | InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1 |
| Inchi Key | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
| SMILES | [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(O)=O |
| Size | 10 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0460/celastrol.html |