Auranofin
Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway. Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5. Potent thioredoxin reductase (TrxR) inhibitor. Induces mitochondrial membrane permeability transition. Anti-cancer compound with anti-proliferative activity. Shown to induce apoptosis and necrosis. STAT3 and telomerase activity inhibitor. Proteasomal deubiquitinase inhibitor. Antibiotic, antiviral and antiparasitic compound. Immunosuppressive.
| Catalog Number | AG-CR1-3611-M100 |
| Alternative Name(s) | 1-Thio-beta-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetra- acetate; NSC 321521; SKF 39162 |
| Research Area | Antibiotic, Apoptosis, Biochemicals, Cancer, Immunology, Inflammation |
| Molecular Formula | C20H34AuO9PS |
| CAS# | 34031-32-8 |
| Purity | >98% |
| Inchi | InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1./s1 |
| Inchi Key | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
| SMILES | CCP(CC)(CC)=[Au]SC1OC(COC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O |
| Size | 100 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3611/auranofin.html |