8-Methoxypsoralen
Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). Has more potency than 5-MOP, 5-OH-P, DH-8-MOP and psoralen in inhibiting CYP2B1 (cytochrome P-450 2B1). Completely inhibits the metabolism of nicotine in vitro. Inhibits the metabolism of caffeine. Methoxsalen is a drug with photoactivating properties used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to UVA light. Upon photoactivation, ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms.
| Catalog Number | CDX-M0156-G005 |
| Alternative Name(s) | 8-MP; 8-MOP; 8-Methoxy-6,7-furanocoumarin; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; 5-Demethoxyisoimpinellin; Ammoidin; Methoxsalen; Xanthotoxin |
| Research Area | Biochemicals, Immunology |
| Molecular Formula | C12H8O4 |
| CAS# | 298-81-7 |
| Purity | >95% |
| Inchi | InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3 |
| Inchi Key | QXKHYNVANLEOEG-UHFFFAOYSA-N |
| SMILES | COC1=C2OC=CC2=CC2=C1OC(=O)C=C2 |
| Size | 5 g |
| Supplier Page | http://www.adipogen.com/cdx-m0156/8-methoxypsoralen.html |