Digoxin
Cardiac glycoside from the leaves of Digitalis lanata. It is used to treat cardiac arrhythmias. It is often used as a model substrate of P-glycoprotein (Pgp) (0.01-10µM) and an inhibitor of Na+/K+-ATPase. Inhibits membrane-bound alpha-subunits of the Na+/K+ ATPase pump in myocytes. The primary mechanism of action involves inhibition of the Na+/K+ ATPase, mainly in the myocardium. This inhibition causes an increase in intracellular sodium levels, resulting in a reversal of the action of the sodium-calcium exchanger, which causes an increase in the intracellular calcium concentration. This leads to a decrease in heart rate and increased storage of calcium in the sarcoplasmic reticulum, causing a corresponding increase in the release of calcium during each action potential.
| Catalog Number | CDX-D0175-G001 |
| Alternative Name(s) | 12beta-Hydroxydigitoxin; NSC 95100 |
| Research Area | Biochemicals, Immunology, Inflammation, Neurobiology |
| Molecular Formula | C41H64O14 |
| CAS# | 20830-75-5 |
| Purity | >95% |
| Inchi | InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1 |
| Inchi Key | LTMHDMANZUZIPE-PUGKRICDSA-N |
| SMILES | [H][C@@]1(C[C@H](O)[C@H](O[C@@]2([H])C[C@H](O)[C@H](O[C@@]3([H])C[C@H](O)[C@H](O)[C@@H](C)O3)[C@@H](C)O2)[C@@H](C)O1)O[C@H]1CC[C@@]2(C)[C@]([H])(CC[C@]3([H])[C@]2([H])C[C@@H](O)[C@]2(C)[C@H](CC[C@]32O)C2=CC(=O)OC2)C1 |
| Size | 1 g |
| Supplier Page | http://www.adipogen.com/cdx-d0175/digoxin.html |