Vincristine . sulfate

Immunosuppressant. Anticancer compound. Chemotherapeutic agent. Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins. Apoptosis inducer and cell cycle inhibitor in G2/M phase. Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme. Inducer of IL-1beta production. Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1beta. Monoamine oxidase (MAO) inhibitor.

Price Not Available 25 mg Vincristine . sulfate Supplier Page

Catalog Number	AG-CN2-0446-M025
Alternative Name(s)	VCR; 22-Oxovincaleukoblastine; NSC 67574; Oncovin; Lilly 37231; Leucristine; Leurocristine; LS-228
Research Area	Autophagy, Biochemicals, Cancer, Natural Products
Molecular Formula	C46H56N4O10 . H2SO4
CAS#	2068-78-2
Purity	>98%
Inchi	InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
Inchi Key	AQTQHPDCURKLKT-JKDPCDLQSA-N
SMILES	OS(O)(=O)=O.[H]C(=O)N1C2=C(C=C(C(OC)=C2)[C@]2(C[C@@H]3C[N@@](C[C@](O)(CC)C3)CCC3=C2NC2=C3C=CC=C2)C(=O)OC)[C@@]23CCN4CC=C[C@@](CC)([C@@H](OC(C)=O)[C@](O)(C(=O)OC)[C@]12[H])[C@@]34[H]
Size	25 mg
Supplier Page	http://www.adipogen.com/ag-cn2-0446/vincristine-sulfate.html