Piperlongumine
Cytotoxic against tumor cell lines. Induces necrosis and apoptosis in cancer cells. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in thromboxane A2 formation. Shows significant anxiolytic and antidepressant activities. Promotes adipogenesis of 3T3-L1 cells. Induces in vivo and in vitro mutagenicity in eukaryotic models. Selectively kills cancer cells by targeting the stress response to ROS. Shows in vitro schistosomicidal activity.
Catalog Number | AG-CN2-0024-M050 |
Alternative Name(s) | Piplartine; 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone |
Research Area | Apoptosis, Cancer, Cell Death, Inflammation, Metabolism, Natural Products, Neurobiology |
Molecular Formula | C17H19NO5 |
CAS# | 20069-09-4 |
Purity | >97% |
Inchi | 1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+ |
Inchi Key | VABYUUZNAVQNPG-BQYQJAHWSA-N |
SMILES | COC1=CC(C=CC(=O)N2CCC=CC2=O)=CC(OC)=C1OC |
Size | 50 mg |
Supplier Page | http://www.adipogen.com/ag-cn2-0024/piperlongumine.html |