Wortmannin

Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Similar potency in vitro for the class I, II, and III PI3K. Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor, regardless of the nutrient status and thus is a more suitable autophagy inhibitor than 3-MA. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. TRAIL sensitizer

Price Not Available 1 mg Wortmannin Supplier Page
Catalog Number AG-CN2-0023-M001
Alternative Name(s) KY 12420; BRN 0067676; NSC 627609; Antibiotic SL-2052
Research Area Antibiotic, Apoptosis, Autophagy, Cancer, Inflammation, Metabolism, Natural Products, Neurobiology, Neurodegenerative Disease
Molecular Formula C23H24O8
CAS# 19545-26-7
Purity >98%
Inchi 1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
Inchi Key QDLHCMPXEPAAMD-QAIWCSMKSA-N
SMILES [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)C2=C3C(=CO2)C(=O)O[C@H](COC)[C@]13C
Size 1 mg
Supplier Page http://www.adipogen.com/ag-cn2-0023/wortmannin.html