PARG Inhibitor PDD00017273
Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies. Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>30µM). Showed no cytotoxicity (IC50>30µM). Poly(ADP ribose) glycohydrolase (PARG) is a critical component in the repair of single strand DNA breaks and therefore a target in cancer cells. PARG counteracts the function of the ARTD family of poly(ADP ribose) polymerases (known as PARPs) by efficiently catalysing the hydrolysis of O-glycosidic linkages of ADP-ribose polymer, thereby reversing the effects of PARPs.
| Catalog Number | AG-CR1-3646-M001 |
| Alternative Name(s) | PARG Inhibitor Compound 4; 1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide |
| Research Area | Biochemicals, Cancer |
| Molecular Formula | C23H26N6O4S2 |
| CAS# | 1945950-21-9 |
| Purity | >98% |
| Inchi | InChI=1S/C23H26N6O4S2/c1-14-9-16(27(4)25-14)12-28-20-6-5-18(35(32,33)26-23(3)7-8-23)10-19(20)21(30)29(22(28)31)13-17-11-24-15(2)34-17/h5-6,9-11,26H,7-8,12-13H2,1-4H3 |
| Inchi Key | IFWUBRBMMNTBRZ-UHFFFAOYSA-N |
| SMILES | O=C(C1=CC(S(NC2(CC2)C)(=O)=O)=CC=C1N3CC4=CC(C)=NN4C)N(CC5=CN=C(C)S5)C3=O |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3646/parg-inhibitor-pdd00017273.html |