Pyridomycin
Cyclodepsipeptide antibiotic. Unusual 12-membered macrocyclic depsipeptide comprises three unique subunits incorporating two substituted pyridines. Potent antitubercular agent. Inhibitor of NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis. Shown to be active against isoniazid-resistant mycobacteria.
| Catalog Number | BVT-0455-MM25 |
| Alternative Name(s) | Antibiotic U 24544; Erizomycin; NSC 246134 |
| Research Area | Antibiotic, Biochemicals, Immunology, Inflammation, Natural Products |
| Molecular Formula | C27H32N4O8 |
| CAS# | 18791-21-4 |
| Purity | >98% |
| Inchi | InChI=1S/C27H32N4O8/c1-5-14(2)23-27(37)38-16(4)20(31-25(35)21-19(32)9-7-11-29-21)24(34)30-18(12-17-8-6-10-28-13-17)22(33)15(3)26(36)39-23/h6-11,13,15-16,18,20,22,32-33H,5,12H2,1-4H3,(H,30,34)(H,31,35)/b23-14-/t15-,16-,18+,20+,22+/m1/s1 |
| Inchi Key | WHIKSLGSXKIHCA-IGCCMALHSA-N |
| SMILES | CCC(C)=C1/OC(=O)[C@H](C)[C@H](O)[C@H](CC2=CC=CN=C2)NC(=O)[C@@H](NC(=O)C2=C(O)C=CC=N2)[C@@H](C)OC1=O |
| Size | 2.5 mg |
| Supplier Page | http://www.adipogen.com/bvt-0455/pyridomycin.html |