(R)-Roscovitine

Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer compound. Kills chronic lymphocytic leukemia (LLC) cells and slows tumor growth in mouse xenografts. Inhibits cysts formation in culture and in polycystic kidney disease (PKD) mouse models. Potential anti-inflammatory compound that can influence the resolution of inflammation. Potential antidiabetic compound. Shown to protect pancreatic beta-cells from glucotoxicity and increase insulin secretion. Shows antiviral properties. Neuroprotective in brain trauma. Has positive effects on Timothy syndrome cells. Used for cloning of mammals by synchronization of nucleus donor cells. Provides neuroprotection in experimental traumatic brain injury.

Price Not Available 25 mg (R)-Roscovitine Supplier Page
Catalog Number AG-MR-C0001-M025
Alternative Name(s) Seliciclib; CYC201; 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine
Research Area Apoptosis, Biochemicals, Cancer, Inflammation, Metabolism
Molecular Formula C19H26N6O
CAS# 186692-46-6
Purity >99%
Inchi InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
Inchi Key BTIHMVBBUGXLCJ-OAHLLOKOSA-N
SMILES CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=CC=C2)=N1
Size 25 mg
Supplier Page http://www.adipogen.com/mr-c0001/-r-roscovitine.html