Apicidin
Antiprotozoal. Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest at the G1 phase. Induces hyperacetylation of histone H4. Apoptosis inducer. Potent anti-angiogenic compound. Decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines. Autophagy inducer in oral squamous cell carcinoma (OSCC) cells. Promotes either self-renewal or differentiation of embryonic stem cells.
| Catalog Number | AG-CN2-0087-M001 |
| Alternative Name(s) | cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]; OSI-2040 |
| Research Area | Apoptosis, Autophagy, Cancer, Immunology, Natural Products, Stem Cell Research |
| Molecular Formula | C34H49N5O6 |
| CAS# | 183506-66-3 |
| Purity | >98% |
| Inchi | InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22?,26-,27-,29+,30-/m0/s1 |
| Inchi Key | JWOGUUIOCYMBPV-LQJYRIKDSA-N |
| SMILES | [H][C@]12CCCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CC1=CN(OC)C3=C1C=CC=C3)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0087/apicidin.html |